Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.54 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.54 |
| ▸ | NPC1 | O15118 | 4/20 | 0.51 |
| ▸ | RAB9A | P51151 | 4/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.51 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.51 |
| ▸ | MAPT | P10636 | 1/20 | 0.51 |
| ▸ | GPR52 | Q9Y2T5 | 1/20 | 0.49 |
| ▸ | MEN1 | O00255 | 2/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.48 |
| ▸ | CES2 | O00748 | 1/20 | 0.48 |
| ▸ | CES1 | P23141 | 1/20 | 0.48 |
| ▸ | PLAAT3 | P53816 | 1/20 | 0.47 |
| ▸ | PLAAT5 | Q96KN8 | 1/20 | 0.47 |
| ▸ | PLAAT2 | Q9NWW9 | 1/20 | 0.47 |
| ▸ | PLAAT4 | Q9UL19 | 1/20 | 0.47 |
| ▸ | GAA | P10253 | 1/20 | 0.45 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.45 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | POLB | P06746 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6497058 | 0.88 | KEAP1 (0.56) | TDP1NPC1RAB9AALDH1A1KDM4E | |
| SCHEMBL6985694 | 0.81 | ALDH1A1 (0.55) | TDP1L3MBTL1NPC1RAB9AALDH1A1 | |
| SCHEMBL6987142 | 0.80 | CES2 (0.52) | TDP1L3MBTL1NPC1RAB9AALDH1A1 | |
| SCHEMBL12330301 | 0.79 | NPC1 (0.70) | TDP1L3MBTL1NPC1RAB9AALDH1A1 | |
| SCHEMBL26850306 | 0.77 | L3MBTL1 (0.55) | TDP1L3MBTL1NPC1RAB9AALDH1A1 | |
| SCHEMBL9121060 | 0.76 | L3MBTL1 (0.62) | TDP1L3MBTL1NPC1RAB9AMAPT | |
| SCHEMBL9576012 | 0.75 | CES2 (0.56) | NPC1RAB9AALDH1A1MAPTMEN1 | |
| SCHEMBL12506243 | 0.74 | TDP1 (0.59) | TDP1L3MBTL1NPC1RAB9AALDH1A1 | |
| SCHEMBL3022199 | 0.74 | TDP1 (0.59) | TDP1L3MBTL1NPC1RAB9AALDH1A1 | |
| SCHEMBL29271945 | 0.74 | L3MBTL1 (0.50) | TDP1L3MBTL1NPC1RAB9AMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0948496-A2 | SUBSTITUTED PYRIMIDINONE AND PYRIDONE COMPOUNDS AND METHODS OF USE | Amgen inc. (US) | 1999-10-13 | — | — | EP | disclosed |
| WO-1998024780-A2 | SUBSTITUTED PYRIMIDINONE AND PYRIDINONE COMPOUNDS AND THEIR USE | AMGEN INC. (US) | 1998-06-11 | — | — | WO | disclosed |