Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MMP2 | P08253 | 3/20 | 0.48 |
| ▸ | MMP9 | P14780 | 3/20 | 0.48 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.48 |
| ▸ | AKR1C1 | Q04828 | 1/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.48 |
| ▸ | GAA | P10253 | 1/20 | 0.48 |
| ▸ | ACHE | P22303 | 1/20 | 0.43 |
| ▸ | ATM | Q13315 | 1/20 | 0.43 |
| ▸ | MMP8 | P22894 | 3/20 | 0.43 |
| ▸ | MMP3 | P08254 | 2/20 | 0.43 |
| ▸ | MMP1 | P03956 | 1/20 | 0.43 |
| ▸ | MMP12 | P39900 | 1/20 | 0.43 |
| ▸ | MMP14 | P50281 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | HTT | P42858 | 1/20 | 0.43 |
| ▸ | GHSR | Q92847 | 3/20 | 0.42 |
| ▸ | CA12 | O43570 | 1/20 | 0.42 |
| ▸ | CA1 | P00915 | 1/20 | 0.42 |
| ▸ | CA2 | P00918 | 1/20 | 0.42 |
| ▸ | CA9 | Q16790 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8327363 | 0.97 | MMP2 (0.48) | MMP2MMP9AKR1C3AKR1C1ALDH1A1 | |
| SCHEMBL13479960 | 0.90 | AKR1C3 (0.39) | MMP2MMP9AKR1C3AKR1C1ALDH1A1 | |
| SCHEMBL2959199 | 0.90 | AKR1C3 (0.39) | MMP2MMP9AKR1C3AKR1C1ALDH1A1 | |
| SCHEMBL8319047 | 0.90 | PSEN1 (0.52) | AKR1C3AKR1C1ACHEMMP8MMP3 | |
| SCHEMBL8319431 | 0.90 | AKR1C3 (0.39) | MMP2MMP9AKR1C3AKR1C1ALDH1A1 | |
| SCHEMBL16298352 | 0.90 | AKR1C3 (0.39) | MMP2MMP9AKR1C3AKR1C1ALDH1A1 | |
| SCHEMBL7971275 | 0.89 | ACHE (0.48) | MMP2ALDH1A1GAAACHEATM | |
| SCHEMBL13201300 | 0.89 | LMNA (0.53) | MMP2MMP9ALDH1A1ATMLMNA | |
| SCHEMBL2969347 | 0.89 | LMNA (0.53) | MMP2MMP9ALDH1A1ATMLMNA | |
| SCHEMBL8320651 | 0.88 | MMP9 (0.62) | MMP2MMP9MMP8MMP3MMP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7772270-B2 | Imino acid derivatives as inhibitors of matrix metalloproteinases | SANOFI-AVENTIS DEUTSCHLAND GMBH (DE) | 2010-08-10 | — | — | US | disclosed |
| US-7772270-B2 | Imino acid derivatives as inhibitors of matrix metalloproteinases | SANOFI-AVENTIS DEUTSCHLAND GMBH (DE) | 2010-08-10 | — | — | US | disclosed |
| WO-2004060874-A1 | IMINO ACID DERIVATIVES FOR USE AS INHIBITORS OF MATRIX METALLOPROTEINASES | AVENTIS PHARMA DEUTSCHLAND GMBH (DE) | 2004-07-22 | — | — | WO | disclosed |