Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACHE | P22303 | 1/20 | 0.49 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.45 |
| ▸ | MMP2 | P08253 | 1/20 | 0.45 |
| ▸ | FAAH | O00519 | 2/20 | 0.43 |
| ▸ | CA1 | P00915 | 1/20 | 0.43 |
| ▸ | CA2 | P00918 | 1/20 | 0.43 |
| ▸ | CA9 | Q16790 | 1/20 | 0.43 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.40 |
| ▸ | MMP8 | P22894 | 7/20 | 0.40 |
| ▸ | MMP3 | P08254 | 4/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2961151 | 0.98 | ACHE (0.52) | ACHEEPHX2MMP2FAAHCA1 | |
| SCHEMBL8319432 | 0.98 | ACHE (0.52) | ACHEEPHX2MMP2FAAHCA1 | |
| SCHEMBL8328565 | 0.94 | ACHE (0.55) | ACHEEPHX2MMP2FAAHAKR1C3 | |
| SCHEMBL2965640 | 0.94 | ACHE (0.55) | ACHEEPHX2MMP2FAAHAKR1C3 | |
| SCHEMBL8327363 | 0.87 | MMP2 (0.48) | MMP2CA1CA2CA9AKR1C3 | |
| SCHEMBL13201328 | 0.86 | CA9 (0.52) | ACHEEPHX2MMP2CA1CA2 | |
| SCHEMBL8328120 | 0.85 | PSEN1 (0.55) | ACHEAKR1C3MMP8MMP3 | |
| SCHEMBL8319435 | 0.84 | MMP2 (0.48) | ACHEMMP2CA1CA2CA9 | |
| SCHEMBL16298352 | 0.82 | AKR1C3 (0.39) | MMP2AKR1C3MMP8MMP3 | |
| SCHEMBL8319431 | 0.82 | AKR1C3 (0.39) | MMP2AKR1C3MMP8MMP3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7772270-B2 | Imino acid derivatives as inhibitors of matrix metalloproteinases | SANOFI-AVENTIS DEUTSCHLAND GMBH (DE) | 2010-08-10 | — | — | US | disclosed |
| WO-2004060874-A1 | IMINO ACID DERIVATIVES FOR USE AS INHIBITORS OF MATRIX METALLOPROTEINASES | AVENTIS PHARMA DEUTSCHLAND GMBH (DE) | 2004-07-22 | — | — | WO | disclosed |