Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NOS2 | P35228 | 2/20 | 0.46 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.39 |
| ▸ | ATM | Q13315 | 2/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.36 |
| ▸ | AR | P10275 | 2/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.35 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.35 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.35 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.35 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.35 |
| ▸ | NOS3 | P29474 | 1/20 | 0.35 |
| ▸ | PDE11A | Q9HCR9 | 1/20 | 0.35 |
| ▸ | NPC1 | O15118 | 2/20 | 0.35 |
| ▸ | HTT | P42858 | 2/20 | 0.35 |
| ▸ | RAB9A | P51151 | 2/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | HPGD | P15428 | 1/20 | 0.34 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.34 |
| ▸ | TOP2A | P11388 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8329748 | 0.88 | NOS2 (0.44) | NOS2L3MBTL1ATMLMNAALDH1A1 | |
| SCHEMBL8325531 | 0.82 | LMNA (0.38) | L3MBTL1ATMLMNAALDH1A1AR | |
| SCHEMBL8259796 | 0.77 | LMNA (0.41) | NOS2L3MBTL1LMNAALDH1A1AR | |
| SCHEMBL12844413 | 0.77 | GRM5 (0.46) | L3MBTL1ALDH1A1SMN1; SMN2CYP1A2CYP3A4 | |
| SCHEMBL8328538 | 0.74 | L3MBTL1 (0.41) | L3MBTL1ATMLMNAALDH1A1CYP1A2 | |
| SCHEMBL8333653 | 0.74 | L3MBTL1 (0.41) | L3MBTL1ATMLMNAALDH1A1CYP1A2 | |
| SCHEMBL5677073 | 0.74 | L3MBTL1 (0.41) | L3MBTL1ATMLMNAALDH1A1CYP1A2 | |
| SCHEMBL4902037 | 0.73 | PDE11A (0.40) | L3MBTL1LMNAALDH1A1ARSMN1; SMN2 | |
| SCHEMBL2494002 | 0.72 | RAB9A (0.59) | L3MBTL1ATMLMNAALDH1A1SMN1; SMN2 | |
| SCHEMBL19310488 | 0.71 | NOS2 (0.47) | NOS2ATMLMNAALDH1A1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5972975-A | Substituted 2-aminopyridines as inhibitors of nitric oxide synthase | MERCK & CO., INC. (US) | 1999-10-26 | — | — | US | disclosed |
| WO-1996018616-A1 | SUBSTITUTED 2-AMINOPYRIDINES AS INHIBITORS OF NITRIC OXIDE SYNTHASE | MERCK & CO., INC. (US) | 1996-06-20 | — | — | WO | disclosed |