Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.37 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.36 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.36 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.36 |
| ▸ | CETP | P11597 | 1/20 | 0.36 |
| ▸ | TOP2A | P11388 | 1/20 | 0.35 |
| ▸ | HTT | P42858 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | ATM | Q13315 | 1/20 | 0.34 |
| ▸ | CFTR | P13569 | 2/20 | 0.34 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.33 |
| ▸ | NPC1 | O15118 | 1/20 | 0.33 |
| ▸ | RAB9A | P51151 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5677073 | 0.76 | L3MBTL1 (0.41) | L3MBTL1LMNAALDH1A1CYP1A2CYP3A4 | |
| SCHEMBL8328538 | 0.76 | L3MBTL1 (0.41) | L3MBTL1LMNAALDH1A1CYP1A2CYP3A4 | |
| SCHEMBL8329748 | 0.76 | NOS2 (0.44) | L3MBTL1LMNAALDH1A1CYP1A2CYP3A4 | |
| SCHEMBL2494002 | 0.74 | RAB9A (0.59) | L3MBTL1LMNAALDH1A1CYP1A2CYP2C9 | |
| SCHEMBL8136438 | 0.74 | L3MBTL1 (0.49) | L3MBTL1ALDH1A1CYP1A2CYP3A4CYP2C9 | |
| SCHEMBL8328435 | 0.74 | NOS2 (0.46) | L3MBTL1LMNAALDH1A1CYP1A2CYP3A4 | |
| SCHEMBL8325531 | 0.72 | LMNA (0.38) | L3MBTL1LMNAALDH1A1CYP1A2CYP3A4 | |
| SCHEMBL27689557 | 0.72 | L3MBTL1 (0.45) | L3MBTL1LMNAALDH1A1CYP1A2CYP3A4 | |
| SCHEMBL8613491 | 0.70 | L3MBTL1 (0.53) | L3MBTL1LMNAALDH1A1CYP1A2CYP3A4 | |
| SCHEMBL2601270 | 0.68 | NPC1 (0.52) | L3MBTL1ALDH1A1MAPTKDM4EATM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5972975-A | Substituted 2-aminopyridines as inhibitors of nitric oxide synthase | MERCK & CO., INC. (US) | 1999-10-26 | — | — | US | disclosed |
| WO-1996018616-A1 | SUBSTITUTED 2-AMINOPYRIDINES AS INHIBITORS OF NITRIC OXIDE SYNTHASE | MERCK & CO., INC. (US) | 1996-06-20 | — | — | WO | disclosed |