Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DPP4 | P27487 | 5/20 | 0.40 |
| ▸ | MKNK1 | Q9BUB5 | 1/20 | 0.40 |
| ▸ | MKNK2 | Q9HBH9 | 1/20 | 0.40 |
| ▸ | TSHR | P16473 | 2/20 | 0.39 |
| ▸ | NNMT | P40261 | 1/20 | 0.38 |
| ▸ | IRAK4 | Q9NWZ3 | 4/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.36 |
| ▸ | HTT | P42858 | 2/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8324245 | 0.88 | TSHR (0.42) | DPP4TSHRLMNACYP3A4 | |
| SCHEMBL8326185 | 0.87 | SLC2A1 (0.40) | DPP4MKNK1MKNK2TSHRNNMT | |
| SCHEMBL8322260 | 0.87 | DPP4 (0.48) | DPP4TSHR | |
| SCHEMBL8562829 | 0.86 | ALDH1A1 (0.38) | DPP4TSHR | |
| SCHEMBL8565727 | 0.80 | KDM4E (0.33) | DPP4TSHRMAPK1LMNACYP3A4 | |
| SCHEMBL8324234 | 0.79 | DPP4 (0.51) | DPP4TSHRLMNA | |
| SCHEMBL27446746 | 0.78 | TP53 (0.41) | DPP4TSHR | |
| SCHEMBL8326372 | 0.78 | TSHR (0.40) | DPP4TSHRHTTLMNA | |
| SCHEMBL8561182 | 0.78 | HSD17B10 (0.36) | TSHRMAPK1HTTLMNACYP3A4 | |
| SCHEMBL8565303 | 0.77 | CSF1R (0.62) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0705260-B1 | CONDENSED 4-AMINOPYRIDINES WITH ANTIRHEUMATIC ACTIVITY | KNOLL AG (DE) | 1999-03-03 | — | — | EP | disclosed |
| US-5780482-A | TREATING RHEUMATIC DISEASES | KNOLL AKTIENGESELLSCHAFT (DE) | 1998-07-14 | — | — | US | disclosed |
| EP-0705260-A1 | CONDENSED 4-AMINOPYRIDINES WITH ANTIRHEUMATIC ACTIVITY | KNOLL AKTIENGESELLSCHAFT (DE) | 1996-04-10 | — | — | EP | disclosed |
| WO-1995000511-A1 | CONDENSED 4-AMINOPYRIDINES WITH ANTIRHEUMATIC ACTIVITY | KNOLL AG (DE) | 1995-01-05 | — | — | WO | disclosed |