Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRM1 | P35372 | 2/20 | 0.43 |
| ▸ | OPRK1 | P41145 | 2/20 | 0.43 |
| ▸ | OGFRL1 | Q5TC84 | 2/20 | 0.43 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.43 |
| ▸ | PDE10A | Q9Y233 | 2/20 | 0.43 |
| ▸ | GPR119 | Q8TDV5 | 1/20 | 0.42 |
| ▸ | NR1H2 | P55055 | 3/20 | 0.41 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.41 |
| ▸ | NAMPT | P43490 | 1/20 | 0.41 |
| ▸ | KCNK3 | O14649 | 3/20 | 0.40 |
| ▸ | KCNK9 | Q9NPC2 | 3/20 | 0.40 |
| ▸ | RORC | P51449 | 1/20 | 0.40 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.40 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.40 |
| ▸ | POLR1A | O95602 | 1/20 | 0.39 |
| ▸ | JAK2 | O60674 | 1/20 | 0.39 |
| ▸ | JAK1 | P23458 | 1/20 | 0.39 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.39 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.39 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8321104 | 1.00 | OPRM1 (0.43) | OPRM1OPRK1OGFRL1OPRD1PDE10A | |
| SCHEMBL8321106 | 1.00 | OPRM1 (0.43) | OPRM1OPRK1OGFRL1OPRD1PDE10A | |
| SCHEMBL615033 | 0.77 | SIGMAR1 (0.63) | NR1H2SIGMAR1 | |
| SCHEMBL6715677 | 0.76 | HTR2A (0.53) | GPR119NR1H2SIGMAR1CHRM2CHRM4 | |
| SCHEMBL22728591 | 0.73 | PDE10A (0.51) | OPRM1OPRK1OGFRL1OPRD1PDE10A | |
| SCHEMBL8653934 | 0.72 | KMT2A (0.46) | OPRM1OPRK1OGFRL1OPRD1PDE10A | |
| SCHEMBL14746435 | 0.71 | CHRNB2 (0.55) | GPR119NR1H2NAMPTRORCJAK2 | |
| SCHEMBL15596306 | 0.71 | GPR119 (0.67) | OPRM1OPRK1OGFRL1OPRD1PDE10A | |
| SCHEMBL10111733 | 0.71 | GPR119 (0.67) | OPRM1OPRK1OGFRL1OPRD1PDE10A | |
| SCHEMBL17953049 | 0.71 | CHRNB2 (0.55) | GPR119NR1H2NAMPTRORCJAK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0470490-B1 | Substituted pyrroles | HOFFMANN LA ROCHE (CH) | 1999-05-06 | — | — | EP | disclosed |
| US-5292747-A | Substituted pyrroles | HOFFMAN-LA ROCHE INC. (US) | 1994-03-08 | — | — | US | disclosed |
| EP-0470490-A1 | Substituted pyrroles | F. HOFFMANN-LA ROCHE AG (CH) | 1992-02-12 | — | — | EP | disclosed |