Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | ERN1 | O75460 | 4/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.32 |
| ▸ | MAPT | P10636 | 2/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.30 |
| ▸ | RAF1 | P04049 | 1/20 | 0.30 |
| ▸ | BRAF | P15056 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8326642 | 0.85 | LMNA (0.47) | LMNAERN1ALDH1A1KDM4EHSD17B10 | |
| SCHEMBL8329005 | 0.82 | ERN1 (0.39) | LMNAERN1ALDH1A1MAPTKDM4E | |
| SCHEMBL24101966 | 0.69 | ERN1 (0.51) | ERN1 | |
| SCHEMBL30855477 | 0.69 | ERN1 (0.51) | ERN1 | |
| SCHEMBL187940 | 0.69 | ALDH1A1 (0.54) | LMNAALDH1A1MAPTKDM4EMEN1 | |
| SCHEMBL28596364 | 0.68 | CCNT1 (0.47) | ALDH1A1MAPTKDM4EKMT2A | |
| SCHEMBL29572281 | 0.68 | CCNT1 (0.47) | ALDH1A1MAPTKDM4EKMT2A | |
| SCHEMBL6781764 | 0.68 | LMNA (0.38) | LMNAERN1ALDH1A1 | |
| SCHEMBL8848754 | 0.68 | GRK6 (0.37) | LMNAALDH1A1MAPT | |
| SCHEMBL27559288 | 0.67 | MAPT (0.43) | LMNAALDH1A1MAPTKDM4EMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0858444-A4 | CYCLOPENTYL TACHYKININ RECEPTOR ANTAGONISTS | MERCK & CO INC (US) | 1999-12-01 | — | — | EP | disclosed |
| EP-0858444-A1 | CYCLOPENTYL TACHYKININ RECEPTOR ANTAGONISTS | Merck & Co., Inc. (US) | 1998-08-19 | — | — | EP | disclosed |
| WO-1997014671-A1 | CYCLOPENTYL TACHYKININ RECEPTOR ANTAGONISTS | MERCK & CO., INC. (US) | 1997-04-24 | — | — | WO | disclosed |