Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IDO1 | P14902 | 2/20 | 0.49 |
| ▸ | TDO2 | P48775 | 2/20 | 0.49 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.44 |
| ▸ | HTR2A | P28223 | 1/20 | 0.42 |
| ▸ | HTR2C | P28335 | 1/20 | 0.42 |
| ▸ | HTR2B | P41595 | 1/20 | 0.42 |
| ▸ | ACP3 | P15309 | 2/20 | 0.41 |
| ▸ | PNMT | P11086 | 1/20 | 0.41 |
| ▸ | ATM | Q13315 | 1/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 2/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8329048 | 0.83 | NPC1 (0.46) | HTR2AHTR2CHTR2BACP3MEN1 | |
| SCHEMBL8322926 | 0.82 | IDO1 (0.52) | IDO1TDO2NFE2L2HTR2AHTR2C | |
| SCHEMBL8326387 | 0.80 | TAAR1 (0.41) | HTR2ASMN1; SMN2MAPTALDH1A1CYP3A4 | |
| SCHEMBL14910878 | 0.79 | TAAR1 (0.50) | HTR2A | |
| SCHEMBL8324571 | 0.78 | TP53 (0.43) | ACP3SMN1; SMN2NPC1MAPTRAB9A | |
| SCHEMBL8328586 | 0.77 | ALDH1A1 (0.46) | IDO1TDO2ACP3PNMTMEN1 | |
| SCHEMBL8322584 | 0.77 | MAOA (0.49) | HTR2ANPC1MAPTMAOB | |
| SCHEMBL20821033 | 0.76 | IDO1 (0.51) | IDO1TDO2HTR2AHTR2CHTR2B | |
| SCHEMBL6309987 | 0.76 | NFE2L2 (0.56) | NFE2L2HTR2AHTR2CHTR2BMEN1 | |
| SCHEMBL6703600 | 0.74 | PNMT (0.47) | IDO1TDO2HTR2AHTR2CHTR2B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0948496-A2 | SUBSTITUTED PYRIMIDINONE AND PYRIDONE COMPOUNDS AND METHODS OF USE | Amgen inc. (US) | 1999-10-13 | — | — | EP | disclosed |
| WO-1998024780-A2 | SUBSTITUTED PYRIMIDINONE AND PYRIDINONE COMPOUNDS AND THEIR USE | AMGEN INC. (US) | 1998-06-11 | — | — | WO | disclosed |