Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 4/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.38 |
| ▸ | MAPT | P10636 | 2/20 | 0.38 |
| ▸ | GAA | P10253 | 2/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | GFER | P55789 | 1/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.38 |
| ▸ | CPN1 | P15169 | 1/20 | 0.37 |
| ▸ | CPB2 | Q96IY4 | 1/20 | 0.37 |
| ▸ | MAOA | P21397 | 4/20 | 0.37 |
| ▸ | CYP3A4 | P08684 | 6/20 | 0.37 |
| ▸ | CYP2D6 | P10635 | 5/20 | 0.37 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.37 |
| ▸ | TSHR | P16473 | 2/20 | 0.37 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.37 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.37 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.37 |
| ▸ | RGS12 | O14924 | 1/20 | 0.37 |
| ▸ | GLA | P06280 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8325683 | 0.81 | CYP3A4 (0.38) | MEN1KMT2AMAPTKDM4ELMNA | |
| SCHEMBL8323859 | 0.81 | MAOA (0.41) | MEN1KMT2AMAPTGAAKDM4E | |
| SCHEMBL8328722 | 0.80 | IDO1 (0.42) | KDM4ESLC6A2SLC6A4 | |
| SCHEMBL27506328 | 0.80 | ACP3 (0.41) | MEN1KMT2AMAPTLMNACYP3A4 | |
| SCHEMBL8326960 | 0.77 | TACR1 (0.38) | MEN1KMT2AMAPTGAAKDM4E | |
| SCHEMBL8324974 | 0.74 | KMT2A (0.40) | MEN1KMT2AMAPTGAAKDM4E | |
| SCHEMBL26185697 | 0.73 | CYP3A4 (0.58) | MEN1KMT2AMAPTGAAKDM4E | |
| SCHEMBL8327275 | 0.72 | SLC6A4 (0.51) | MEN1KMT2AMAPTKDM4ECYP3A4 | |
| SCHEMBL8323402 | 0.71 | PBRM1 (0.50) | MEN1KMT2AMAPTGAALMNA | |
| SCHEMBL31226606 | 0.71 | MAPKAPK2 (0.46) | MEN1KMT2ACPN1CPB2CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0948496-A2 | SUBSTITUTED PYRIMIDINONE AND PYRIDONE COMPOUNDS AND METHODS OF USE | Amgen inc. (US) | 1999-10-13 | — | — | EP | disclosed |
| WO-1998024780-A2 | SUBSTITUTED PYRIMIDINONE AND PYRIDINONE COMPOUNDS AND THEIR USE | AMGEN INC. (US) | 1998-06-11 | — | — | WO | disclosed |