Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LTA4H | P09960 | 3/20 | 0.52 |
| ▸ | MMP8 | P22894 | 1/20 | 0.40 |
| ▸ | SYK | P43405 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.39 |
| ▸ | LMNA | P02545 | 2/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | RECQL | P46063 | 1/20 | 0.38 |
| ▸ | SLC7A5 | Q01650 | 1/20 | 0.37 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.37 |
| ▸ | AAK1 | Q2M2I8 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | CRHBP | P24387 | 1/20 | 0.36 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.36 |
| ▸ | PIN1 | Q13526 | 1/20 | 0.36 |
| ▸ | PSMB5 | P28074 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8803290 | 0.90 | LTA4H (0.46) | LTA4HMMP8ALDH1A1RECQLSLC7A5 | |
| SCHEMBL8799769 | 0.89 | LTA4H (0.41) | LTA4HKMT2ALMNAALDH1A1L3MBTL1 | |
| SCHEMBL8799063 | 0.88 | LTA4H (0.45) | LTA4HMMP8LMNASMN1; SMN2 | |
| SCHEMBL8798762 | 0.87 | LTA4H (0.41) | LTA4HKMT2AALDH1A1SMN1; SMN2 | |
| SCHEMBL8800040 | 0.85 | LTA4H (0.42) | LTA4HKMT2ALMNAMAPTALDH1A1 | |
| SCHEMBL8633545 | 0.83 | SLC7A5 (0.43) | LTA4HMMP8KMT2ALMNAALDH1A1 | |
| SCHEMBL8798260 | 0.80 | LTA4H (0.38) | LTA4HKMT2ASMN1; SMN2 | |
| SCHEMBL8331038 | 0.78 | CYP4F2 (0.33) | LTA4HALDH1A1 | |
| SCHEMBL29447511 | 0.78 | LTA4H (0.57) | LTA4HSYKALDH1A1SLC7A5L3MBTL1 | |
| SCHEMBL8799950 | 0.78 | ALDH1A1 (0.38) | LTA4HMAPTALDH1A1L3MBTL1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5908863-A | ANTIGROWTH AGENT FOR BONES | DOMPE' S.P.A. (IT) | 1999-06-01 | — | — | US | disclosed |
| EP-0792878-A2 | Geminal carboxylic acids and esters thereof, pharmaceutical formulations containing them useful in the treatment of bone dysmetabolism | Dompé S.P.A. (IT) | 1997-09-03 | — | — | EP | disclosed |