Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MTNR1B | P49286 | 6/20 | 0.39 |
| ▸ | MTNR1A | P48039 | 5/20 | 0.39 |
| ▸ | NQO2 | P16083 | 3/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | TP53 | P04637 | 1/20 | 0.37 |
| ▸ | RAB9A | P51151 | 1/20 | 0.37 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.37 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8334169 | 0.87 | MTNR1B (0.38) | MTNR1BMTNR1ANQO2KDM4EALDH1A1 | |
| SCHEMBL8331376 | 0.84 | MEN1 (0.36) | — | |
| SCHEMBL8333896 | 0.83 | MAPT (0.44) | MTNR1BMTNR1ANQO2ALDH1A1RAB9A | |
| SCHEMBL8335532 | 0.81 | TDP1 (0.41) | MTNR1BMTNR1ARAB9AALOX5 | |
| SCHEMBL8716979 | 0.81 | FFAR1 (0.38) | MTNR1BMTNR1ANQO2RAB9A | |
| SCHEMBL8331864 | 0.80 | APP (0.38) | — | |
| SCHEMBL8331862 | 0.80 | APP (0.38) | — | |
| SCHEMBL8335539 | 0.80 | TDP1 (0.38) | MTNR1BMTNR1A | |
| SCHEMBL8332882 | 0.80 | HTR2A (0.47) | MTNR1BMTNR1A | |
| SCHEMBL8329351 | 0.80 | HTR2A (0.47) | MTNR1BMTNR1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5753709-A | N-acyl-2 aryl cyclopropylmethylamine derivatives as melatonergics | BRISTOL-MYERS SQUIBB COMPANY (US) | 1998-05-19 | — | — | US | claimed |
| US-5889031-A | CONTROLLING CIRCADIAN RHYTHMS | BRISTOL-MYERS SQUIBB COMPNAY (US) | 1999-03-30 | — | — | US | disclosed |
| US-5753709-A | N-acyl-2 aryl cyclopropylmethylamine derivatives as melatonergics | BRISTOL-MYERS SQUIBB COMPANY (US) | 1998-05-19 | — | — | US | disclosed |