Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.41 |
| ▸ | ALOX5 | P09917 | 2/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | MTNR1A | P48039 | 4/20 | 0.39 |
| ▸ | MTNR1B | P49286 | 3/20 | 0.39 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.38 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.38 |
| ▸ | PLA2G4A | P47712 | 1/20 | 0.38 |
| ▸ | CYP24A1 | Q07973 | 1/20 | 0.38 |
| ▸ | PLA2G2A | P14555 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8330324 | 0.81 | MTNR1B (0.39) | ALOX5MTNR1AMTNR1BRAB9A | |
| SCHEMBL8716979 | 0.80 | FFAR1 (0.38) | MEN1KMT2AMTNR1AMTNR1BNPC1 | |
| SCHEMBL8334169 | 0.80 | MTNR1B (0.38) | L3MBTL1ALOX5MTNR1AMTNR1BRAB9A | |
| SCHEMBL8335539 | 0.79 | TDP1 (0.38) | TDP1MEN1KMT2AMTNR1AMTNR1B | |
| SCHEMBL8101935 | 0.77 | MTNR1A (0.56) | MEN1KMT2AMTNR1AMTNR1B | |
| SCHEMBL8333896 | 0.76 | MAPT (0.44) | MTNR1AMTNR1BNPC1RAB9A | |
| SCHEMBL8332882 | 0.75 | HTR2A (0.47) | MTNR1AMTNR1BSIGMAR1 | |
| SCHEMBL8329351 | 0.75 | HTR2A (0.47) | MTNR1AMTNR1BSIGMAR1 | |
| SCHEMBL8330940 | 0.71 | MAOA (0.49) | SIGMAR1OPRM1 | |
| SCHEMBL8330943 | 0.71 | MAOA (0.49) | SIGMAR1OPRM1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5889031-A | CONTROLLING CIRCADIAN RHYTHMS | BRISTOL-MYERS SQUIBB COMPNAY (US) | 1999-03-30 | — | — | US | disclosed |
| US-5753709-A | N-acyl-2 aryl cyclopropylmethylamine derivatives as melatonergics | BRISTOL-MYERS SQUIBB COMPANY (US) | 1998-05-19 | — | — | US | disclosed |