SCHEMBL8330356

SCHEMBL8330356

COc1cccc([C@@H]2[C@@H](COC(C)=O)C2(F)F)c1

nearest known ligand 0.44

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
SLC9A1 P19634 2/20 0.44
CACNA1D Q01668 2/20 0.40
CACNA1F O60840 1/20 0.40
CACNA1S Q13698 1/20 0.40
CACNA1C Q13936 1/20 0.40
ALDH1A1 P00352 3/20 0.40
KDM4E B2RXH2 2/20 0.40
DDB1 Q16531 1/20 0.40
CRBN Q96SW2 1/20 0.40
GLA P06280 1/20 0.40
GAA P10253 1/20 0.40
HPGD P15428 1/20 0.40
TSHR P16473 1/20 0.39
CA12 O43570 2/20 0.39
CA1 P00915 2/20 0.39
CA9 Q16790 2/20 0.39
MTNR1A P48039 1/20 0.39
MTNR1B P49286 1/20 0.39
CA2 P00918 1/20 0.39
MEN1 O00255 2/20 0.38

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL9198675 0.82 HTR2A (0.51) SLC9A1CACNA1DALDH1A1TSHRKMT2A
SCHEMBL7975868 0.82 HTR2A (0.51) SLC9A1CACNA1DALDH1A1TSHRKMT2A
SCHEMBL9198668 0.82 HTR2A (0.51) SLC9A1CACNA1DALDH1A1TSHRKMT2A
SCHEMBL15715833 0.82 HTR2A (0.51) SLC9A1CACNA1DALDH1A1TSHRKMT2A
SCHEMBL8332475 0.78 HTR2C (0.58) SLC9A1ALDH1A1KDM4EDDB1CRBN
SCHEMBL8333226 0.77 SLC9A1 (0.47) SLC9A1CACNA1DCACNA1FCACNA1SCACNA1C
SCHEMBL8098211 0.76 MTNR1A (0.43) SLC9A1CACNA1DCACNA1FCACNA1SCACNA1C
SCHEMBL8098209 0.76 MTNR1A (0.43) SLC9A1CACNA1DCACNA1FCACNA1SCACNA1C
SCHEMBL8103541 0.75 MTNR1B (0.50) MTNR1AMTNR1B
SCHEMBL8103536 0.75 MTNR1B (0.50) MTNR1AMTNR1B

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-5889031-A CONTROLLING CIRCADIAN RHYTHMS BRISTOL-MYERS SQUIBB COMPNAY (US) 1999-03-30 US disclosed
US-5753709-A N-acyl-2 aryl cyclopropylmethylamine derivatives as melatonergics BRISTOL-MYERS SQUIBB COMPANY (US) 1998-05-19 US disclosed