Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MTNR1A | P48039 | 10/20 | 0.43 |
| ▸ | NQO2 | P16083 | 2/20 | 0.43 |
| ▸ | CACNA1F | O60840 | 1/20 | 0.42 |
| ▸ | CACNA1D | Q01668 | 1/20 | 0.42 |
| ▸ | CACNA1S | Q13698 | 1/20 | 0.42 |
| ▸ | CACNA1C | Q13936 | 1/20 | 0.42 |
| ▸ | MTNR1B | P49286 | 11/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.41 |
| ▸ | GLA | P06280 | 2/20 | 0.41 |
| ▸ | GAA | P10253 | 2/20 | 0.41 |
| ▸ | HPGD | P15428 | 2/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.41 |
| ▸ | SLC9A1 | P19634 | 1/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
| ▸ | CASP1 | P29466 | 1/20 | 0.41 |
| ▸ | CASP7 | P55210 | 1/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8098209 | 1.00 | MTNR1A (0.43) | MTNR1ANQO2CACNA1FCACNA1DCACNA1S | |
| SCHEMBL8103541 | 0.83 | MTNR1B (0.50) | MTNR1AMTNR1B | |
| SCHEMBL8103536 | 0.83 | MTNR1B (0.50) | MTNR1AMTNR1B | |
| SCHEMBL8088503 | 0.76 | HTR2A (0.56) | MTNR1ANQO2MTNR1BSLC9A1 | |
| SCHEMBL8088502 | 0.76 | HTR2A (0.56) | MTNR1ANQO2MTNR1BSLC9A1 | |
| SCHEMBL8330356 | 0.76 | SLC9A1 (0.44) | MTNR1ACACNA1FCACNA1DCACNA1SCACNA1C | |
| SCHEMBL8333226 | 0.75 | SLC9A1 (0.47) | MTNR1ACACNA1FCACNA1DCACNA1SCACNA1C | |
| SCHEMBL8332475 | 0.74 | HTR2C (0.58) | ALDH1A1KDM4EGAASLC9A1 | |
| SCHEMBL8334052 | 0.74 | SLC9A1 (0.43) | MTNR1ACACNA1FCACNA1DCACNA1SCACNA1C | |
| SCHEMBL8096225 | 0.70 | MTNR1B (0.51) | MTNR1AMTNR1BSLC9A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0747346-B1 | N-acyl-2 aryl cyclopropylmethylamine derivatives as melatonergics | BRISTOL MYERS SQUIBB CO (US) | 2000-02-16 | — | — | EP | disclosed |
| EP-0747346-A2 | N-acyl-2 aryl cyclopropylmethylamine derivatives as melatonergics | BRISTOL-MYERS SQUIBB COMPANY (US) | 1996-12-11 | — | — | EP | disclosed |