SCHEMBL8333036

SCHEMBL8333036

Clc1cc(C#CCN2CCC(c3ccccc3)CC2)ccc1C1CCCCC1

nearest known ligand 0.41

Predicted protein targets (top 13)

geneUniProtsupporting neighboursconfidence
MEN1 O00255 1/20 0.41
KMT2A Q03164 1/20 0.41
GRIN1 Q05586 6/20 0.41
GRIN2B Q13224 4/20 0.41
CHRM2 P08172 1/20 0.40
CHRM4 P08173 1/20 0.40
CHRM5 P08912 1/20 0.40
CHRM1 P11229 1/20 0.40
CHRM3 P20309 1/20 0.40
LMNA P02545 1/20 0.40
SLC18A3 Q16572 4/20 0.39
SIGMAR1 Q99720 1/20 0.39
DRD2 P14416 2/20 0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL27466986 0.86 GRIN1 (0.59) GRIN1GRIN2B
Hydrochloric Acid SCHEMBL7325272 0.85 MEN1 (0.42) MEN1KMT2AGRIN1GRIN2BCHRM2
Hydrochloric Acid SCHEMBL7313723 0.85 GRIN1 (0.58) GRIN1GRIN2B
SCHEMBL8523461 0.84 LMNA (0.53) MEN1KMT2AGRIN1GRIN2BCHRM2
Hydrochloric Acid SCHEMBL7325842 0.83 LMNA (0.51) MEN1KMT2AGRIN1GRIN2BCHRM2
SCHEMBL27468416 0.82 DRD2 (0.50) GRIN1GRIN2BSIGMAR1DRD2
Hydrochloric Acid SCHEMBL7325377 0.80 LMNA (0.40) GRIN1LMNADRD2
Hydrochloric Acid SCHEMBL6139683 0.76 LMNA (0.46) MEN1KMT2AGRIN1LMNADRD2
SCHEMBL25317343 0.74 SIGMAR1 (0.38) SIGMAR1
SCHEMBL27482620 0.73 SLC18A3 (0.47) MEN1KMT2ASLC18A3SIGMAR1DRD2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20230364033-A1 COMPOUNDS FOR TREATING VIRUS INFECTIONS MELETIOS THERAPEUTICS (FR) 2023-11-16 US disclosed
EP-4213822-A1 COMPOUNDS FOR TREATING VIRUS INFECTIONS MELETIOS Therapeutics (FR) 2023-07-26 EP disclosed
CN-116437960-A Compounds for the treatment of viral infections 梅莱蒂奥斯治疗 2023-07-14 CN disclosed
WO-2022058533-A1 COMPOUNDS FOR TREATING VIRUS INFECTIONS MELETIOS THERAPEUTICS (FR) 2022-03-24 WO disclosed
EP-0917464-A1 USE OF AMINES TO PRODUCE DRUGS FOR PREVENTING TUMOUR CELL PROLIFERATION SANOFI (FR) 1999-05-26 EP disclosed
WO-1998004251-A1 USE OF AMINES TO PRODUCE DRUGS FOR PREVENTING TUMOUR CELL PROLIFERATION SANOFI (FR) 1998-02-05 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20230364033-A1 COMPOUNDS FOR TREATING VIRUS INFECTIONS ACE, HAVCR2, FURIN MEN1 704/4885KMT2A 2884/4885GRIN1 2707/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.