Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RARB | P10826 | 8/20 | 0.42 |
| ▸ | RARG | P13631 | 7/20 | 0.42 |
| ▸ | RARA | P10276 | 6/20 | 0.42 |
| ▸ | MAPT | P10636 | 2/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
| ▸ | PPARG | P37231 | 1/20 | 0.36 |
| ▸ | PPARA | Q07869 | 1/20 | 0.34 |
| ▸ | TNF | P01375 | 1/20 | 0.34 |
| ▸ | KLF5 | Q13887 | 1/20 | 0.34 |
| ▸ | NOD1 | Q9Y239 | 1/20 | 0.34 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.34 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.34 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.34 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | THRB | P10828 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8329424 | 0.87 | RARA (0.42) | RARBRARGRARAMAPTPPARG | |
| SCHEMBL6594110 | 0.83 | RARB (0.60) | RARBRARGRARA | |
| SCHEMBL6592790 | 0.82 | RARB (0.46) | RARBRARGRARAMAPTPPARG | |
| SCHEMBL8335170 | 0.81 | RARB (0.44) | RARBRARGRARAPPARGPPARA | |
| SCHEMBL6589881 | 0.76 | RARA (0.45) | RARBRARGRARAMAPTPPARA | |
| SCHEMBL6592317 | 0.75 | RARA (0.56) | RARBRARGRARAOPRD1 | |
| SCHEMBL8328656 | 0.72 | RARB (0.48) | RARBRARGRARANPC1RAB9A | |
| SCHEMBL6590859 | 0.72 | RARA (0.52) | RARBRARGRARAMAPTTDP1 | |
| SCHEMBL6593231 | 0.72 | RARA (0.67) | RARBRARGRARA | |
| SCHEMBL6596504 | 0.71 | RARA (0.60) | RARBRARGRARAALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5958954-A | 2,2-DIALKYL-4-ARYL-SUBSTITUTED BENZOPYRAN AND BENZOTHIOPYRAN DERIVATIVES | ALLERGAN SALES, INC. (US) | 1999-09-28 | — | — | US | disclosed |