Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RARB | P10826 | 5/20 | 0.41 |
| ▸ | RARA | P10276 | 4/20 | 0.41 |
| ▸ | RARG | P13631 | 4/20 | 0.41 |
| ▸ | PPARG | P37231 | 1/20 | 0.34 |
| ▸ | PPARA | Q07869 | 1/20 | 0.33 |
| ▸ | AKR1C2 | P52895 | 1/20 | 0.32 |
| ▸ | AKR1C1 | Q04828 | 1/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.32 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.32 |
| ▸ | GFER | P55789 | 1/20 | 0.32 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.32 |
| ▸ | RORB | Q92753 | 1/20 | 0.31 |
| ▸ | DHODH | Q02127 | 1/20 | 0.31 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.31 |
| ▸ | TRPV1 | Q8NER1 | 2/20 | 0.30 |
| ▸ | RXRA | P19793 | 1/20 | 0.30 |
| ▸ | RXRB | P28702 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8332455 | 0.91 | RARA (0.44) | RARBRARARARGPPARGPPARA | |
| SCHEMBL8331802 | 0.89 | RARA (0.52) | RARBRARARARGPPARGOPRD1 | |
| SCHEMBL8331104 | 0.88 | RARA (0.41) | RARBRARARARGPPARGPPARA | |
| SCHEMBL8329425 | 0.87 | RARA (0.41) | RARBRARARARGDHODHOPRD1 | |
| SCHEMBL8331248 | 0.81 | RARB (0.38) | RARBRARARARGAKR1C2AKR1C1 | |
| SCHEMBL8335170 | 0.77 | RARB (0.44) | RARBRARARARGPPARGPPARA | |
| SCHEMBL6594110 | 0.73 | RARB (0.60) | RARBRARARARGRXRARXRB | |
| SCHEMBL24727636 | 0.73 | RARB (0.52) | RARBRARARARGOPRD1RXRA | |
| SCHEMBL8335174 | 0.70 | RARB (0.42) | RARBRARARARGPPARGPPARA | |
| SCHEMBL12365151 | 0.66 | RARA (0.63) | RARBRARARARGOPRD1RXRA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5958954-A | 2,2-DIALKYL-4-ARYL-SUBSTITUTED BENZOPYRAN AND BENZOTHIOPYRAN DERIVATIVES | ALLERGAN SALES, INC. (US) | 1999-09-28 | — | — | US | disclosed |