Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADRB2 | P07550 | 5/20 | 0.43 |
| ▸ | ADRB1 | P08588 | 5/20 | 0.43 |
| ▸ | CYP2D6 | P10635 | 4/20 | 0.43 |
| ▸ | ADRB3 | P13945 | 2/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 4/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.38 |
| ▸ | HTR1A | P08908 | 2/20 | 0.38 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.38 |
| ▸ | ADRA1A | P35348 | 2/20 | 0.38 |
| ▸ | SLC22A1 | O15245 | 1/20 | 0.38 |
| ▸ | HTR2A | P28223 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.37 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.36 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.36 |
| ▸ | BDKRB2 | P30411 | 1/20 | 0.36 |
| ▸ | HTR2B | P41595 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21363141 | 0.76 | LMNA (0.46) | KDM4EALDH1A1LMNACYP1A2MAPT | |
| SCHEMBL10516249 | 0.73 | MAPT (0.49) | CYP2D6KDM4EALDH1A1LMNAMAPT | |
| SCHEMBL18663141 | 0.72 | KDM4E (0.42) | KDM4ETDP1ALDH1A1LMNACYP1A2 | |
| SCHEMBL31349926 | 0.70 | LMNA (0.48) | ADRB2ADRB1CYP2D6ADRB3ALDH1A1 | |
| SCHEMBL21363140 | 0.68 | TDP1 (0.41) | TDP1ALDH1A1LMNACYP1A2SLC6A2 | |
| SCHEMBL23963353 | 0.67 | ADRB2 (0.57) | ADRB2ADRB1CYP2D6ADRB3KDM4E | |
| SCHEMBL10703868 | 0.66 | THRB (0.41) | CYP2D6KDM4EALDH1A1LMNAMAPT | |
| SCHEMBL11524082 | 0.66 | KMT2A (0.40) | ADRB2ADRB1CYP2D6ADRB3KDM4E | |
| SCHEMBL7897828 | 0.66 | SIGMAR1 (0.67) | ADRB2ADRB1CYP2D6ADRB3KDM4E | |
| SCHEMBL7868616 | 0.65 | ADRB2 (0.58) | ADRB2ADRB1CYP2D6ADRB3LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5958429-A | TREATING DEPRESSION | ELI LILLY AND COMPANY (US) | 1999-09-28 | — | — | US | disclosed |