Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CNR2 | P34972 | 2/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.37 |
| ▸ | GPR88 | Q9GZN0 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.36 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.36 |
| ▸ | PLK1 | P53350 | 1/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.36 |
| ▸ | NPY5R | Q15761 | 1/20 | 0.36 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.35 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.35 |
| ▸ | MMP1 | P03956 | 1/20 | 0.35 |
| ▸ | AOC3 | Q16853 | 1/20 | 0.35 |
| ▸ | AKR1C3 | P42330 | 3/20 | 0.35 |
| ▸ | AKR1C2 | P52895 | 3/20 | 0.35 |
| ▸ | AKR1C1 | Q04828 | 1/20 | 0.35 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8335851 | 0.88 | CNR2 (0.38) | CNR2ALDH1A1GPR88KMT2ASLC6A2 | |
| SCHEMBL8389782 | 0.88 | GPR88 (0.36) | CNR2ALDH1A1GPR88KMT2APLK1 | |
| SCHEMBL8338167 | 0.86 | HPGD (0.39) | CNR2GPR88PLK1L3MBTL1OPRM1 | |
| SCHEMBL8334276 | 0.83 | ALOX5 (0.34) | CNR2ALDH1A1GPR88KMT2AHSD17B10 | |
| SCHEMBL8334765 | 0.79 | HPGD (0.37) | CNR2ALDH1A1GPR88KMT2APLK1 | |
| SCHEMBL8334832 | 0.79 | CNR2 (0.37) | CNR2ALDH1A1GPR88KMT2APLK1 | |
| SCHEMBL8336148 | 0.79 | KMT2A (0.38) | CNR2ALDH1A1KMT2A | |
| SCHEMBL8340993 | 0.79 | EPHX2 (0.36) | CNR2ALDH1A1GPR88KMT2A | |
| SCHEMBL8336209 | 0.77 | GPR88 (0.35) | CNR2ALDH1A1GPR88KMT2AOPRM1 | |
| SCHEMBL8334475 | 0.76 | CNR1 (0.33) | CNR2ALDH1A1KMT2AL3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5977177-A | Substituted benzenesulfonylureas and-thioureas, processes for their preparation and use of pharmaceutical preparations based on these compounds, and medicaments containing them | HOECHST AKTIENGESELLSCHAFT (DE) | 1999-11-02 | — | — | US | disclosed |
| US-5880155-A | TREATMENT OF CARDIOVASCULAR DISORDERS | HOECHST AKTIENGESELLSCHAFT (DE) | 1999-03-09 | — | — | US | disclosed |