Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EPHX2 | P34913 | 2/20 | 0.36 |
| ▸ | CA1 | P00915 | 1/20 | 0.35 |
| ▸ | CA2 | P00918 | 1/20 | 0.35 |
| ▸ | MMP2 | P08253 | 1/20 | 0.35 |
| ▸ | MMP9 | P14780 | 1/20 | 0.35 |
| ▸ | CA9 | Q16790 | 1/20 | 0.35 |
| ▸ | HSD11B1 | P28845 | 2/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.33 |
| ▸ | MEN1 | O00255 | 3/20 | 0.33 |
| ▸ | CNR2 | P34972 | 2/20 | 0.33 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.33 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.32 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.32 |
| ▸ | GPR88 | Q9GZN0 | 2/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8341066 | 0.80 | — | — | |
| SCHEMBL8336148 | 0.80 | KMT2A (0.38) | EPHX2MMP2MMP9HSD11B1KMT2A | |
| SCHEMBL8336540 | 0.79 | CNR2 (0.40) | KMT2ACNR2ALDH1A1GPR88 | |
| SCHEMBL8338167 | 0.77 | HPGD (0.39) | MMP9CNR2LMNAGPR88 | |
| SCHEMBL8339597 | 0.74 | KMT2A (0.37) | EPHX2KMT2AMEN1 | |
| SCHEMBL8335851 | 0.73 | CNR2 (0.38) | KMT2AMEN1CNR2CYP2C19ALDH1A1 | |
| SCHEMBL8334832 | 0.71 | CNR2 (0.37) | CA1CA2KMT2AMEN1CNR2 | |
| SCHEMBL8334765 | 0.71 | HPGD (0.37) | MMP9KMT2AMEN1CNR2ALDH1A1 | |
| SCHEMBL8389782 | 0.68 | GPR88 (0.36) | KMT2AMEN1CNR2CYP2D6ALDH1A1 | |
| SCHEMBL8391019 | 0.68 | EPHX2 (0.51) | EPHX2KMT2ACYP2D6CYP2C19ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5977177-A | Substituted benzenesulfonylureas and-thioureas, processes for their preparation and use of pharmaceutical preparations based on these compounds, and medicaments containing them | HOECHST AKTIENGESELLSCHAFT (DE) | 1999-11-02 | — | — | US | disclosed |
| US-5880155-A | TREATMENT OF CARDIOVASCULAR DISORDERS | HOECHST AKTIENGESELLSCHAFT (DE) | 1999-03-09 | — | — | US | disclosed |