Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGD | P15428 | 1/20 | 0.37 |
| ▸ | CNR2 | P34972 | 2/20 | 0.37 |
| ▸ | AKR1C3 | P42330 | 3/20 | 0.35 |
| ▸ | AKR1C2 | P52895 | 3/20 | 0.35 |
| ▸ | AKR1C1 | Q04828 | 1/20 | 0.35 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.35 |
| ▸ | ADAM17 | P78536 | 4/20 | 0.35 |
| ▸ | MMP1 | P03956 | 2/20 | 0.35 |
| ▸ | MMP9 | P14780 | 2/20 | 0.35 |
| ▸ | MMP13 | P45452 | 2/20 | 0.35 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.34 |
| ▸ | GAA | P10253 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | GPR88 | Q9GZN0 | 1/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.34 |
| ▸ | HTT | P42858 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8338167 | 0.89 | HPGD (0.39) | HPGDCNR2AKR1C3AKR1C2AKR1C1 | |
| SCHEMBL8389972 | 0.89 | ALDH1A1 (0.34) | CNR2ALDH1A1MEN1KMT2APOLB | |
| SCHEMBL8340209 | 0.89 | ADAM17 (0.36) | HPGDCNR2ADAM17MMP1MMP9 | |
| SCHEMBL8335851 | 0.86 | CNR2 (0.38) | CNR2AKR1C3AKR1C2AKR1C1PTGS1 | |
| SCHEMBL8334832 | 0.84 | CNR2 (0.37) | CNR2TDP1ALDH1A1GAAMAPT | |
| SCHEMBL8339597 | 0.79 | KMT2A (0.37) | MAPTMEN1KMT2A | |
| SCHEMBL8336540 | 0.79 | CNR2 (0.40) | CNR2AKR1C3AKR1C2AKR1C1PTGS1 | |
| SCHEMBL8337030 | 0.78 | MMP1 (0.35) | HPGDCNR2ADAM17MMP1MMP9 | |
| SCHEMBL8333490 | 0.76 | — | — | |
| SCHEMBL8336209 | 0.75 | GPR88 (0.35) | CNR2ADAM17MMP1MMP9MMP13 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5977177-A | Substituted benzenesulfonylureas and-thioureas, processes for their preparation and use of pharmaceutical preparations based on these compounds, and medicaments containing them | HOECHST AKTIENGESELLSCHAFT (DE) | 1999-11-02 | — | — | US | disclosed |
| US-5880155-A | TREATMENT OF CARDIOVASCULAR DISORDERS | HOECHST AKTIENGESELLSCHAFT (DE) | 1999-03-09 | — | — | US | disclosed |