Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.60 |
| ▸ | MAPT | P10636 | 4/20 | 0.60 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.60 |
| ▸ | HAO1 | Q9UJM8 | 1/20 | 0.53 |
| ▸ | LMNA | P02545 | 3/20 | 0.52 |
| ▸ | HTT | P42858 | 2/20 | 0.52 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.52 |
| ▸ | MEN1 | O00255 | 1/20 | 0.52 |
| ▸ | GAA | P10253 | 1/20 | 0.52 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.52 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.52 |
| ▸ | RELA | Q04206 | 1/20 | 0.52 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.52 |
| ▸ | POLB | P06746 | 1/20 | 0.51 |
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.46 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.46 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.46 |
| ▸ | BCL2L1 | Q07817 | 2/20 | 0.43 |
| ▸ | MCL1 | Q07820 | 2/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11754496 | 0.82 | ALDH1A1 (0.67) | ALDH1A1MAPTSMN1; SMN2HAO1LMNA | |
| SCHEMBL28606431 | 0.79 | ALDH1A1 (0.67) | ALDH1A1MAPTSMN1; SMN2HAO1LMNA | |
| SCHEMBL8340977 | 0.79 | NPC1 (0.54) | ALDH1A1MAPTSMN1; SMN2LMNAMEN1 | |
| SCHEMBL8341523 | 0.77 | L3MBTL1 (0.49) | ALDH1A1MAPTSMN1; SMN2LMNAHTT | |
| SCHEMBL8335416 | 0.77 | KDM4E (0.47) | ALDH1A1LMNAKDM4EKMT2APOLB | |
| SCHEMBL8341968 | 0.77 | NPC1 (0.51) | ALDH1A1MAPTSMN1; SMN2LMNAKDM4E | |
| SCHEMBL8338985 | 0.76 | ESR2 (0.56) | ALDH1A1MAPTSMN1; SMN2LMNAHTT | |
| SCHEMBL27316749 | 0.75 | HDAC8 (0.62) | ALDH1A1MAPTHAO1LMNAHDAC8 | |
| SCHEMBL8339223 | 0.75 | MAPT (0.51) | ALDH1A1MAPTSMN1; SMN2HAO1LMNA | |
| SCHEMBL11567237 | 0.75 | HAO1 (0.66) | ALDH1A1MAPTSMN1; SMN2HAO1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5968975-A | TREATING ATHEROSCLEROSIS | AMERICAN HOME PRODUCTS CORPORATION (US) | 1999-10-19 | — | — | US | disclosed |
| WO-1998057925-A1 | ELEVATION OF HDL CHOLESTEROL BY 2-[(AMINOTHIOXOMETHYL)-HYDRAZONO]-2-ARYLETHYL CARBAMATES | AMERICAN HOME PRODUCTS CORPORATION (US) | 1998-12-23 | — | — | WO | disclosed |