Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | APEX1 | P27695 | 1/20 | 0.39 |
| ▸ | CASP6 | P55212 | 1/20 | 0.39 |
| ▸ | S100A4 | P26447 | 2/20 | 0.36 |
| ▸ | PTPRC | P08575 | 1/20 | 0.36 |
| ▸ | NQO1 | P15559 | 1/20 | 0.35 |
| ▸ | F2RL3 | Q96RI0 | 1/20 | 0.35 |
| ▸ | MAOB | P27338 | 1/20 | 0.34 |
| ▸ | MAPK13 | O15264 | 1/20 | 0.33 |
| ▸ | EIF2AK2 | P19525 | 1/20 | 0.33 |
| ▸ | MAPK12 | P53778 | 1/20 | 0.33 |
| ▸ | MAPK11 | Q15759 | 1/20 | 0.33 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.33 |
| ▸ | USP8 | P40818 | 1/20 | 0.32 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
| ▸ | CSNK2A2 | P19784 | 1/20 | 0.32 |
| ▸ | CSNK2B | P67870 | 1/20 | 0.32 |
| ▸ | CSNK2A1 | P68400 | 1/20 | 0.32 |
| ▸ | CSNK2A3 | Q8NEV1 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8340204 | 0.86 | TOP2A (0.41) | MAPTS100A4PTPRCMAPK13EIF2AK2 | |
| SCHEMBL8336928 | 0.83 | ADORA2A (0.42) | POLBMAPTPTPRCMAPK13EIF2AK2 | |
| SCHEMBL8340182 | 0.83 | MAOA (0.38) | POLBMAPTAPEX1MAPK13EIF2AK2 | |
| SCHEMBL8172006 | 0.80 | EIF2AK2 (0.54) | POLBMAPTAPEX1MAPK13EIF2AK2 | |
| SCHEMBL8336811 | 0.73 | TOP2A (0.45) | MAPTMAOBMAPK13EIF2AK2MAPK12 | |
| SCHEMBL8337451 | 0.73 | TOP2A (0.45) | POLBMAPTMAPK13EIF2AK2MAPK12 | |
| SCHEMBL5109566 | 0.65 | MAPT (0.79) | POLBMAPTAPEX1CASP6S100A4 | |
| SCHEMBL1456997 | 0.65 | CNR2 (0.48) | MAPTF2RL3LMNACYP1A2 | |
| SCHEMBL8336886 | 0.63 | MAPT (0.55) | POLBMAPTAPEX1CASP6S100A4 | |
| SCHEMBL2298153 | 0.62 | MAPT (0.69) | POLBMAPTAPEX1CASP6S100A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7335676-B2 | Methods for treating inflammatory conditions or inhibiting JNK | SIGNAL PHARMACEUTICALS, LLC (US) | 2008-02-26 | — | — | US | disclosed |
| WO-2004084891-A1 | METHODS FOR TREATING INFLAMMATORY CONDITIONS OR INHIBITING JNK | SIGNAL PHARMACEUTICALS, LLC (US) | 2004-10-07 | — | — | WO | disclosed |