Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MMP9 | P14780 | 4/20 | 0.40 |
| ▸ | MMP13 | P45452 | 4/20 | 0.40 |
| ▸ | ADAM17 | P78536 | 4/20 | 0.40 |
| ▸ | MMP1 | P03956 | 3/20 | 0.40 |
| ▸ | EPHX2 | P34913 | 3/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.36 |
| ▸ | POLB | P06746 | 2/20 | 0.36 |
| ▸ | NPC1 | O15118 | 2/20 | 0.36 |
| ▸ | RAB9A | P51151 | 2/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.35 |
| ▸ | SMYD3 | Q9H7B4 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 2/20 | 0.34 |
| ▸ | CNR1 | P21554 | 1/20 | 0.34 |
| ▸ | CNR2 | P34972 | 1/20 | 0.34 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.34 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.34 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.34 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.34 |
| ▸ | YAP1 | P46937 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8341075 | 0.92 | NPC1 (0.39) | MMP9MMP13ADAM17MMP1ALDH1A1 | |
| SCHEMBL8340696 | 0.88 | RAB9A (0.46) | EPHX2ALDH1A1NPC1RAB9ASMN1; SMN2 | |
| SCHEMBL8337089 | 0.88 | MMP9 (0.43) | MMP9MMP13ADAM17MMP1POLB | |
| SCHEMBL8336849 | 0.87 | MMP9 (0.44) | MMP9MMP13ADAM17MMP1POLB | |
| SCHEMBL8339304 | 0.87 | MMP9 (0.42) | MMP9MMP13ADAM17MMP1ALDH1A1 | |
| SCHEMBL8334058 | 0.86 | MMP9 (0.41) | MMP9MMP13ADAM17MMP1ALDH1A1 | |
| SCHEMBL8340431 | 0.85 | MMP9 (0.39) | MMP9MMP13ADAM17MMP1POLB | |
| SCHEMBL8334670 | 0.82 | MMP9 (0.41) | MMP9MMP13ADAM17MMP1POLB | |
| SCHEMBL8336310 | 0.81 | MMP9 (0.43) | MMP9MMP13ADAM17MMP1POLB | |
| SCHEMBL8332853 | 0.81 | MMP9 (0.41) | MMP9MMP13ADAM17MMP1CNR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5977177-A | Substituted benzenesulfonylureas and-thioureas, processes for their preparation and use of pharmaceutical preparations based on these compounds, and medicaments containing them | HOECHST AKTIENGESELLSCHAFT (DE) | 1999-11-02 | — | — | US | disclosed |
| US-5880155-A | TREATMENT OF CARDIOVASCULAR DISORDERS | HOECHST AKTIENGESELLSCHAFT (DE) | 1999-03-09 | — | — | US | disclosed |