Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
| ▸ | MMP9 | P14780 | 4/20 | 0.39 |
| ▸ | MMP13 | P45452 | 4/20 | 0.39 |
| ▸ | ADAM17 | P78536 | 4/20 | 0.39 |
| ▸ | MMP1 | P03956 | 3/20 | 0.39 |
| ▸ | BMP1 | P13497 | 1/20 | 0.37 |
| ▸ | HTT | P42858 | 3/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.34 |
| ▸ | CRHBP | P24387 | 1/20 | 0.34 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.34 |
| ▸ | SMYD3 | Q9H7B4 | 1/20 | 0.34 |
| ▸ | CNR1 | P21554 | 1/20 | 0.34 |
| ▸ | CNR2 | P34972 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.33 |
| ▸ | LMNA | P02545 | 2/20 | 0.33 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.33 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.33 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.33 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8340696 | 0.96 | RAB9A (0.46) | NPC1RAB9ABMP1HTTKDM4E | |
| SCHEMBL8339718 | 0.92 | MMP9 (0.40) | NPC1RAB9AMMP9MMP13ADAM17 | |
| SCHEMBL8334670 | 0.89 | MMP9 (0.41) | MMP9MMP13ADAM17MMP1HTT | |
| SCHEMBL8332853 | 0.88 | MMP9 (0.41) | MMP9MMP13ADAM17MMP1HTT | |
| SCHEMBL8392500 | 0.88 | MMP9 (0.43) | MMP9MMP13ADAM17MMP1HTT | |
| SCHEMBL8336310 | 0.88 | MMP9 (0.43) | MMP9MMP13ADAM17MMP1HTT | |
| SCHEMBL8340743 | 0.87 | MMP9 (0.40) | MMP9MMP13ADAM17MMP1HTT | |
| SCHEMBL8338841 | 0.86 | MMP9 (0.40) | MMP9MMP13ADAM17MMP1HTT | |
| SCHEMBL8338140 | 0.86 | MMP9 (0.38) | MMP9MMP13ADAM17MMP1HTT | |
| SCHEMBL8337089 | 0.83 | MMP9 (0.43) | MMP9MMP13ADAM17MMP1CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5977177-A | Substituted benzenesulfonylureas and-thioureas, processes for their preparation and use of pharmaceutical preparations based on these compounds, and medicaments containing them | HOECHST AKTIENGESELLSCHAFT (DE) | 1999-11-02 | — | — | US | disclosed |
| US-5880155-A | TREATMENT OF CARDIOVASCULAR DISORDERS | HOECHST AKTIENGESELLSCHAFT (DE) | 1999-03-09 | — | — | US | disclosed |