Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAB9A | P51151 | 4/20 | 0.46 |
| ▸ | NPC1 | O15118 | 3/20 | 0.46 |
| ▸ | BMP1 | P13497 | 1/20 | 0.42 |
| ▸ | HTT | P42858 | 3/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 3/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.39 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.39 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.39 |
| ▸ | LMNA | P02545 | 2/20 | 0.39 |
| ▸ | YAP1 | P46937 | 2/20 | 0.39 |
| ▸ | TEAD4 | Q15561 | 2/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8341075 | 0.96 | NPC1 (0.39) | RAB9ANPC1BMP1HTTALDH1A1 | |
| SCHEMBL8339718 | 0.88 | MMP9 (0.40) | RAB9ANPC1ALDH1A1EPHX2MAPT | |
| SCHEMBL8340743 | 0.87 | MMP9 (0.40) | HTTALDH1A1MAPTLMNAKDM4E | |
| SCHEMBL8334670 | 0.87 | MMP9 (0.41) | HTTCYP3A4CYP2C19KDM4ETDP1 | |
| SCHEMBL8332853 | 0.86 | MMP9 (0.41) | HTTKDM4EKMT2ACNR1CNR2 | |
| SCHEMBL8392500 | 0.86 | MMP9 (0.43) | HTTKDM4ETDP1 | |
| SCHEMBL8336310 | 0.86 | MMP9 (0.43) | HTTKDM4ETDP1 | |
| SCHEMBL8338841 | 0.84 | MMP9 (0.40) | HTTALDH1A1MAPTLMNAKDM4E | |
| SCHEMBL8338140 | 0.84 | MMP9 (0.38) | HTTALDH1A1MAPTSMN1; SMN2CYP3A4 | |
| SCHEMBL8334058 | 0.81 | MMP9 (0.41) | ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5977177-A | Substituted benzenesulfonylureas and-thioureas, processes for their preparation and use of pharmaceutical preparations based on these compounds, and medicaments containing them | HOECHST AKTIENGESELLSCHAFT (DE) | 1999-11-02 | — | — | US | disclosed |
| US-5880155-A | TREATMENT OF CARDIOVASCULAR DISORDERS | HOECHST AKTIENGESELLSCHAFT (DE) | 1999-03-09 | — | — | US | disclosed |