Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD3 | P35462 | 3/20 | 0.36 |
| ▸ | DRD2 | P14416 | 3/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.34 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.34 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.33 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.33 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.33 |
| ▸ | PKM | P14618 | 1/20 | 0.33 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | EDNRB | P24530 | 1/20 | 0.33 |
| ▸ | EDNRA | P25101 | 1/20 | 0.33 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.33 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8335504 | 0.92 | TDP1 (0.35) | DRD3DRD2KDM4EALDH1A1HDAC1 | |
| SCHEMBL8338913 | 0.77 | SMN1; SMN2 (0.36) | ALDH1A1HDAC1HDAC8CYP1A2CYP3A4 | |
| SCHEMBL8340133 | 0.69 | TDP1 (0.37) | KDM4EALDH1A1CYP1A2CYP3A4CYP2C9 | |
| SCHEMBL8336185 | 0.68 | TDP1 (0.38) | KDM4EALDH1A1SMN1; SMN2 | |
| SCHEMBL8339013 | 0.67 | CNR2 (0.33) | CYP1A2CYP3A4CYP2C9PKMCYP2C19 | |
| SCHEMBL8335797 | 0.64 | OPRK1 (0.41) | KDM4EALDH1A1CYP1A2CYP3A4CYP2C9 | |
| SCHEMBL8339176 | 0.64 | OPRM1 (0.39) | KDM4ECYP1A2CYP2C9CYP2C19KMT2A | |
| SCHEMBL24217664 | 0.59 | DRD2 (0.47) | DRD3DRD2SMN1; SMN2 | |
| SCHEMBL8556874 | 0.59 | DRD2 (0.43) | DRD3DRD2SMN1; SMN2POLB | |
| SCHEMBL8574688 | 0.58 | PLK1 (0.47) | KDM4EALDH1A1KMT2ASMN1; SMN2EDNRB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5977177-A | Substituted benzenesulfonylureas and-thioureas, processes for their preparation and use of pharmaceutical preparations based on these compounds, and medicaments containing them | HOECHST AKTIENGESELLSCHAFT (DE) | 1999-11-02 | — | — | US | disclosed |
| US-5880155-A | TREATMENT OF CARDIOVASCULAR DISORDERS | HOECHST AKTIENGESELLSCHAFT (DE) | 1999-03-09 | — | — | US | disclosed |