Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.38 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.38 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.38 |
| ▸ | TACR1 | P25103 | 1/20 | 0.35 |
| ▸ | UBE2N | P61088 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.35 |
| ▸ | NPC1 | O15118 | 2/20 | 0.34 |
| ▸ | RAB9A | P51151 | 2/20 | 0.34 |
| ▸ | FPR1 | P21462 | 1/20 | 0.34 |
| ▸ | FPR2 | P25090 | 1/20 | 0.34 |
| ▸ | BACE1 | P56817 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8340133 | 0.94 | TDP1 (0.37) | TDP1OPRM1OPRK1UBE2NKDM4E | |
| SCHEMBL8336462 | 0.92 | OPRK1 (0.39) | OPRM1OPRK1TACR1KDM4EFPR1 | |
| SCHEMBL8338913 | 0.85 | SMN1; SMN2 (0.36) | OPRM1OPRK1FPR1FPR2SMN1; SMN2 | |
| SCHEMBL8340904 | 0.84 | GAA (0.33) | TACR1RAB9ASMN1; SMN2ALDH1A1LMNA | |
| SCHEMBL8335504 | 0.77 | TDP1 (0.35) | TDP1UBE2NKDM4ENPC1RAB9A | |
| SCHEMBL8339931 | 0.71 | TDP1 (0.48) | TDP1KDM4ERAB9ASMN1; SMN2ALDH1A1 | |
| SCHEMBL8339200 | 0.68 | DRD3 (0.36) | KDM4ESMN1; SMN2ALDH1A1 | |
| SCHEMBL8335900 | 0.67 | TDP1 (0.46) | TDP1KDM4ERAB9ASMN1; SMN2ALDH1A1 | |
| SCHEMBL8335612 | 0.63 | LMNA (0.40) | TDP1KDM4ENPC1RAB9ASMN1; SMN2 | |
| SCHEMBL8335797 | 0.63 | OPRK1 (0.41) | OPRM1OPRK1KDM4EBACE1HSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5977177-A | Substituted benzenesulfonylureas and-thioureas, processes for their preparation and use of pharmaceutical preparations based on these compounds, and medicaments containing them | HOECHST AKTIENGESELLSCHAFT (DE) | 1999-11-02 | — | — | US | disclosed |
| US-5880155-A | TREATMENT OF CARDIOVASCULAR DISORDERS | HOECHST AKTIENGESELLSCHAFT (DE) | 1999-03-09 | — | — | US | disclosed |