Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.35 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.35 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.35 |
| ▸ | PKM | P14618 | 1/20 | 0.35 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.35 |
| ▸ | FPR1 | P21462 | 1/20 | 0.35 |
| ▸ | FPR2 | P25090 | 1/20 | 0.35 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.35 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.34 |
| ▸ | LMNA | P02545 | 2/20 | 0.34 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.34 |
| ▸ | EDNRB | P24530 | 3/20 | 0.34 |
| ▸ | EDNRA | P25101 | 3/20 | 0.34 |
| ▸ | TSHR | P16473 | 1/20 | 0.33 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.33 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8340133 | 0.91 | TDP1 (0.37) | SMN1; SMN2CYP1A2CYP3A4CYP2C9PKM | |
| SCHEMBL8336185 | 0.85 | TDP1 (0.38) | SMN1; SMN2FPR1FPR2OPRM1OPRK1 | |
| SCHEMBL8339200 | 0.77 | DRD3 (0.36) | SMN1; SMN2CYP1A2CYP3A4CYP2C9PKM | |
| SCHEMBL8335504 | 0.69 | TDP1 (0.35) | SMN1; SMN2PKMCYP2C19KMT2AMEN1 | |
| SCHEMBL8335797 | 0.68 | OPRK1 (0.41) | CYP1A2CYP3A4CYP2C9PKMCYP2C19 | |
| SCHEMBL8339176 | 0.67 | OPRM1 (0.39) | SMN1; SMN2CYP1A2CYP2C9CYP2C19KMT2A | |
| SCHEMBL8339931 | 0.63 | TDP1 (0.48) | SMN1; SMN2CYP3A4CYP2C9CYP2C19KMT2A | |
| SCHEMBL8864591 | 0.61 | MAPT (0.32) | CYP1A2CYP3A4CYP2C9PKMCYP2C19 | |
| SCHEMBL28836843 | 0.61 | OPRK1 (0.55) | CYP1A2CYP2C9CYP2C19KMT2AOPRM1 | |
| SCHEMBL8340378 | 0.60 | HTT (0.44) | SMN1; SMN2KMT2AMEN1ALDH1A1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5977177-A | Substituted benzenesulfonylureas and-thioureas, processes for their preparation and use of pharmaceutical preparations based on these compounds, and medicaments containing them | HOECHST AKTIENGESELLSCHAFT (DE) | 1999-11-02 | — | — | US | disclosed |
| US-5880155-A | TREATMENT OF CARDIOVASCULAR DISORDERS | HOECHST AKTIENGESELLSCHAFT (DE) | 1999-03-09 | — | — | US | disclosed |