Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.46 |
| ▸ | MAPT | P10636 | 2/20 | 0.46 |
| ▸ | LMNA | P02545 | 1/20 | 0.46 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.46 |
| ▸ | HTT | P42858 | 1/20 | 0.46 |
| ▸ | GFER | P55789 | 1/20 | 0.46 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.46 |
| ▸ | CNR1 | P21554 | 1/20 | 0.45 |
| ▸ | CNR2 | P34972 | 1/20 | 0.45 |
| ▸ | DRD2 | P14416 | 1/20 | 0.43 |
| ▸ | DRD4 | P21917 | 1/20 | 0.43 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.43 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | TP53 | P04637 | 1/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
| ▸ | DHFR | P00374 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8828657 | 0.90 | ALDH1A1 (0.49) | ALDH1A1MAPTLMNAMAPK1HTT | |
| SCHEMBL27536578 | 0.84 | DRD2 (0.43) | MAPTMAPK1DRD2DRD4HDAC3 | |
| SCHEMBL27678018 | 0.84 | SIGMAR1 (0.53) | MAPTLMNADRD2DRD4HDAC3 | |
| SCHEMBL10936598 | 0.76 | MAPT (0.71) | ALDH1A1MAPTLMNAMAPK1HTT | |
| SCHEMBL8223307 | 0.76 | KDM4E (0.62) | DRD2DRD4KDM4E | |
| SCHEMBL8981809 | 0.74 | MAPT (0.57) | ALDH1A1MAPTLMNAMAPK1HTT | |
| SCHEMBL13875126 | 0.74 | KDM4E (0.69) | DRD2DRD4KDM4E | |
| SCHEMBL27409046 | 0.74 | DRD2 (0.42) | ALDH1A1MAPTGFERDRD2DRD4 | |
| SCHEMBL27413682 | 0.73 | DRD2 (0.56) | ALDH1A1MAPTLMNAMAPK1GFER | |
| Hydrochloric Acid SCHEMBL11550862 | 0.73 | GNAI3 (0.61) | ALDH1A1HTTTDP1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5889010-A | PSYCHOLOGICAL DISORDERS; UROGENITAL DISORDERS; COGNITION ACTIVATORS; NERVOUS SYSTEM DISORDERS; VISION DEFECTS; CONGESTIVE HEART FAILURE; DRUG ABRUSE; PARKINSON'S DISEASE;ANTIINFLAMMATORY AGENTS; ANTIALLERGENS | PFIZER INC. (US) | 1999-03-30 | — | — | US | disclosed |