Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.52 |
| ▸ | GFER | P55789 | 1/20 | 0.49 |
| ▸ | MAPT | P10636 | 8/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.49 |
| ▸ | LMNA | P02545 | 1/20 | 0.49 |
| ▸ | POLB | P06746 | 1/20 | 0.49 |
| ▸ | GAA | P10253 | 1/20 | 0.49 |
| ▸ | DRD2 | P14416 | 2/20 | 0.46 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.46 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.45 |
| ▸ | NPC1 | O15118 | 1/20 | 0.44 |
| ▸ | RAB9A | P51151 | 1/20 | 0.44 |
| ▸ | MMP13 | P45452 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6744187 | 0.84 | GFER (0.47) | GFERMAPTALDH1A1LMNAPOLB | |
| SCHEMBL6664679 | 0.81 | SMN1; SMN2 (0.51) | SMN1; SMN2GFERMAPTALDH1A1POLB | |
| SCHEMBL8343166 | 0.75 | DRD2 (0.48) | SMN1; SMN2GFERMAPTALDH1A1LMNA | |
| SCHEMBL16562244 | 0.74 | RAB9A (0.74) | SMN1; SMN2MAPTALDH1A1POLBGAA | |
| SCHEMBL6835489 | 0.74 | SMN1; SMN2 (0.51) | SMN1; SMN2GFERMAPTALDH1A1LMNA | |
| SCHEMBL6686372 | 0.73 | ALDH1A1 (0.49) | SMN1; SMN2MAPTALDH1A1POLBDRD2 | |
| SCHEMBL6678354 | 0.73 | DRD2 (0.54) | GFERMAPTALDH1A1LMNAPOLB | |
| SCHEMBL6670427 | 0.73 | ALDH1A1 (0.49) | SMN1; SMN2GFERMAPTALDH1A1LMNA | |
| SCHEMBL6682647 | 0.72 | ALDH1A1 (0.47) | SMN1; SMN2GFERMAPTALDH1A1POLB | |
| SCHEMBL5745194 | 0.71 | MCL1 (0.50) | ALDH1A1GAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2004014389-A1 | 3,4-DIHYDROQUINOLIN-2-ONE, 5,6-FUSED OXAZIN-3-ONE, AND 5,6-FUSED THIAZIN-3-ONE DERIVATIVES AS MATRIX METALLOPROTEINASE INHIBITORS | WARNER-LAMBERT COMPANY LLC (US) | 2004-02-19 | — | — | WO | disclosed |