Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 3/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | PKM | P14618 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 2/20 | 0.36 |
| ▸ | GAA | P10253 | 2/20 | 0.36 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.36 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.34 |
| ▸ | ALOX5AP | P20292 | 4/20 | 0.34 |
| ▸ | FEN1 | P39748 | 4/20 | 0.34 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.33 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.33 |
| ▸ | TSHR | P16473 | 1/20 | 0.33 |
| ▸ | PTGES2 | Q9H7Z7 | 1/20 | 0.32 |
| ▸ | GRM5 | P41594 | 1/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8346167 | 0.72 | PTGS2 (0.50) | ALDH1A1GAAPTGS2ALOX5APFEN1 | |
| SCHEMBL15366568 | 0.70 | FEN1 (0.54) | ALDH1A1PTGS2ALOX5APFEN1HSD11B1 | |
| SCHEMBL8346365 | 0.64 | PTGS2 (0.56) | PTGS2 | |
| SCHEMBL9908753 | 0.63 | PKM (0.64) | KMT2AALDH1A1MEN1MAPTPKM | |
| SCHEMBL791010 | 0.62 | PTGES2 (0.54) | ALDH1A1LMNAALOX5APFEN1TSHR | |
| SCHEMBL8344047 | 0.62 | PTGS2 (0.51) | PTGS2ALOX5APFEN1 | |
| SCHEMBL4731653 | 0.62 | CYP1A2 (0.55) | ALDH1A1LMNAGAAALOX5APFEN1 | |
| SCHEMBL1621373 | 0.62 | ALDH1A1 (0.67) | KMT2AALDH1A1MAPTGAAALOX5AP | |
| SCHEMBL29689413 | 0.61 | SLC40A1 (0.51) | KMT2AALDH1A1LMNAGAAALOX5AP | |
| SCHEMBL4860115 | 0.61 | PTGS2 (0.57) | PTGS2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5932598-A | NOVEL SUBSTITUTED SULFONAMIDE COMPOUNDS USEFUL AS PRODRUGS; ADMINISTERING TO TREAT INFLAMMATION-ASSOCIATED PAIN DUE TO CANCER, DENTAL PAIN; CYCLOOXYGENASE-2 INHIBITORS | G. D. SEARLE & CO. (US) | 1999-08-03 | — | — | US | disclosed |