Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPR119 | Q8TDV5 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 7/20 | 0.37 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.37 |
| ▸ | MT-CO2 | P00403 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 4/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.37 |
| ▸ | RAB9A | P51151 | 2/20 | 0.37 |
| ▸ | NPC1 | O15118 | 1/20 | 0.37 |
| ▸ | MITF | O75030 | 1/20 | 0.37 |
| ▸ | TP53 | P04637 | 1/20 | 0.37 |
| ▸ | XBP1 | P17861 | 1/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.37 |
| ▸ | HTT | P42858 | 1/20 | 0.37 |
| ▸ | UBE2N | P61088 | 1/20 | 0.37 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.37 |
| ▸ | TLR9 | Q9NR96 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.35 |
| ▸ | LCK | P06239 | 3/20 | 0.35 |
| ▸ | AKR1C3 | P42330 | 2/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8342236 | 0.78 | GPX4 (0.39) | MAPTMT-CO2ALDH1A1RAB9ANPC1 | |
| SCHEMBL278961 | 0.75 | SYK (0.39) | MAPTL3MBTL1MT-CO2LMNAALDH1A1 | |
| SCHEMBL8344153 | 0.74 | MT-CO2 (0.36) | MAPTMT-CO2ALDH1A1NPC1NPSR1 | |
| SCHEMBL1476113 | 0.72 | GPR119 (0.36) | GPR119MAPTMT-CO2LMNAALDH1A1 | |
| SCHEMBL17537442 | 0.71 | LCK (0.41) | MAPTMT-CO2LCK | |
| SCHEMBL29023026 | 0.71 | GPR119 (0.47) | GPR119MAPTLMNAALDH1A1RAB9A | |
| SCHEMBL9960220 | 0.70 | GPR119 (0.44) | GPR119MAPTLMNAALDH1A1RAB9A | |
| SCHEMBL1674179 | 0.69 | MAPKAPK5 (0.39) | GPR119IDH1 | |
| SCHEMBL3994283 | 0.69 | LMNA (0.41) | LMNAALDH1A1HTTNPSR1TSHR | |
| SCHEMBL31086578 | 0.67 | MEN1 (0.40) | MAPTL3MBTL1MT-CO2LMNAALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2256108-B1 | SUBSTITUTED TRIAZINE KINASE INHIBITORS | JANSSEN PHARMACEUTICA NV (BE) | 2016-03-23 | — | — | EP | disclosed |
| EP-1546121-B1 | SUBSTITUTED TRIAZINE KINASE INHIBITORS | JANSSEN PHARMACEUTICA NV (BE) | 2012-08-29 | — | — | EP | disclosed |
| EP-2256108-A1 | Substituted triazine kinase inhibitors | Janssen Pharmaceutica NV (BE) | 2010-12-01 | — | — | EP | disclosed |
| US-7205298-B2 | Substituted triazine kinase inhibitors | JANSSEN PHARMACEUTICA N.V. (BE) | 2007-04-17 | — | — | US | disclosed |
| US-7205298-B2 | Substituted triazine kinase inhibitors | JANSSEN PHARMACEUTICA N.V. (BE) | 2007-04-17 | — | — | US | disclosed |
| WO-2004009562-A1 | SUBSTITUTED TRIAZINE KINASE INHIBITORS | JANSSEN PHARMACEUTICA, NV (BE) | 2004-01-29 | — | — | WO | disclosed |