Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MT-CO2 | P00403 | 1/20 | 0.36 |
| ▸ | CDK1 | P06493 | 1/20 | 0.36 |
| ▸ | RXRA | P19793 | 1/20 | 0.35 |
| ▸ | RXRB | P28702 | 1/20 | 0.35 |
| ▸ | RXRG | P48443 | 1/20 | 0.35 |
| ▸ | XPO1 | O14980 | 1/20 | 0.35 |
| ▸ | EGFR | P00533 | 3/20 | 0.35 |
| ▸ | SRC | P12931 | 1/20 | 0.35 |
| ▸ | LIPE | Q05469 | 1/20 | 0.35 |
| ▸ | CSF1R | P07333 | 2/20 | 0.34 |
| ▸ | CNR2 | P34972 | 2/20 | 0.34 |
| ▸ | CNR1 | P21554 | 1/20 | 0.34 |
| ▸ | PTGIR | P43119 | 1/20 | 0.33 |
| ▸ | PTGDR | Q13258 | 1/20 | 0.33 |
| ▸ | RORC | P51449 | 1/20 | 0.33 |
| ▸ | F2 | P00734 | 1/20 | 0.33 |
| ▸ | GRM5 | P41594 | 2/20 | 0.33 |
| ▸ | HSD17B1 | P14061 | 1/20 | 0.33 |
| ▸ | HSD17B2 | P37059 | 1/20 | 0.33 |
| ▸ | NPC1 | O15118 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8342236 | 0.79 | GPX4 (0.39) | MT-CO2NPC1ALDH1A1MAPT | |
| SCHEMBL278961 | 0.76 | SYK (0.39) | MT-CO2NPC1ALDH1A1GAAMAPT | |
| SCHEMBL4672209 | 0.74 | RXRA (0.38) | MT-CO2RXRARXRBRXRGXPO1 | |
| SCHEMBL8346290 | 0.74 | GPR119 (0.39) | MT-CO2NPC1ALDH1A1MAPTNPSR1 | |
| SCHEMBL3512522 | 0.74 | KMO (0.42) | XPO1CNR2RORCF2 | |
| SCHEMBL29004748 | 0.73 | HTR3E (0.51) | LIPECNR2HSD17B1HSD17B2NPC1 | |
| SCHEMBL4947246 | 0.73 | EGFR (0.47) | RXRARXRBRXRGEGFRCSF1R | |
| SCHEMBL30455057 | 0.73 | HTR3E (0.51) | LIPECNR2HSD17B1HSD17B2NPC1 | |
| SCHEMBL1010292 | 0.72 | MT-CO2 (0.40) | MT-CO2XPO1LIPEHSD17B1HSD17B2 | |
| SCHEMBL15550751 | 0.72 | HTR3E (0.43) | MT-CO2XPO1LIPEHSD17B1HSD17B2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2256108-B1 | SUBSTITUTED TRIAZINE KINASE INHIBITORS | JANSSEN PHARMACEUTICA NV (BE) | 2016-03-23 | — | — | EP | disclosed |
| EP-1546121-B1 | SUBSTITUTED TRIAZINE KINASE INHIBITORS | JANSSEN PHARMACEUTICA NV (BE) | 2012-08-29 | — | — | EP | disclosed |
| EP-2256108-A1 | Substituted triazine kinase inhibitors | Janssen Pharmaceutica NV (BE) | 2010-12-01 | — | — | EP | disclosed |
| US-7205298-B2 | Substituted triazine kinase inhibitors | JANSSEN PHARMACEUTICA N.V. (BE) | 2007-04-17 | — | — | US | disclosed |
| US-7205298-B2 | Substituted triazine kinase inhibitors | JANSSEN PHARMACEUTICA N.V. (BE) | 2007-04-17 | — | — | US | disclosed |
| WO-2004009562-A1 | SUBSTITUTED TRIAZINE KINASE INHIBITORS | JANSSEN PHARMACEUTICA, NV (BE) | 2004-01-29 | — | — | WO | disclosed |