Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CTSK | P43235 | 6/20 | 0.67 |
| ▸ | CTSS | P25774 | 3/20 | 0.50 |
| ▸ | CAPN1 | P07384 | 4/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.40 |
| ▸ | CCR1 | P32246 | 1/20 | 0.39 |
| ▸ | NPC1 | O15118 | 4/20 | 0.39 |
| ▸ | RAB9A | P51151 | 4/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | CTSV | O60911 | 2/20 | 0.39 |
| ▸ | CTSL | P07711 | 2/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8348382 | 0.92 | CTSK (0.57) | CTSKCTSSMAPK1NPC1RAB9A | |
| SCHEMBL6237263 | 0.89 | CTSK (0.52) | CTSKCTSSNPC1RAB9ASMN1; SMN2 | |
| SCHEMBL5942080 | 0.85 | CTSK (0.88) | CTSKCTSSCCR1CTSVCTSL | |
| SCHEMBL5942073 | 0.85 | CTSK (0.88) | CTSKCTSSCCR1CTSVCTSL | |
| SCHEMBL8347258 | 0.83 | CTSK (0.84) | CTSKCTSSCCR1CTSVCTSL | |
| SCHEMBL4369357 | 0.83 | CTSK (0.84) | CTSKCTSSCCR1CTSVCTSL | |
| SCHEMBL4369360 | 0.83 | CTSK (0.84) | CTSKCTSSCCR1CTSVCTSL | |
| SCHEMBL4369353 | 0.83 | CTSK (0.84) | CTSKCTSSCCR1CTSVCTSL | |
| SCHEMBL8348054 | 0.83 | CTSK (0.68) | CTSKCTSSCTSVCTSL | |
| SCHEMBL6233220 | 0.83 | CHRNB2 (0.48) | CTSKCAPN1MAPK1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1546150-B1 | PYRROLE DERIVATIVES AS INHIBITORS OF CYTEINE PROTEASES | AMURA THERAPEUTICS LTD (GB) | 2009-03-04 | — | — | EP | disclosed |
| WO-2004007501-A1 | BIOLOGICALLY ACTIVE COMPOUNDS | AMURA THERAPEUTICS LIMITED (GB) | 2004-01-22 | — | — | WO | disclosed |