SCHEMBL8348333

SCHEMBL8348333

CCCCc1nc(OC)c(C=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)N(Cc2ccccc2)C(=O)O)cc1

nearest known ligand 0.55

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
AGTR2 P50052 5/20 0.48
AGTR1 P30556 4/20 0.48

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8348331 0.89 MAS1 (0.46) AGTR2AGTR1
SCHEMBL8550486 0.81 AGTR2 (0.56) AGTR2
SCHEMBL7612134 0.78 AGTR2 (0.47) AGTR2AGTR1
SCHEMBL1459519 0.76 GP6 (0.65) AGTR2AGTR1
SCHEMBL1457880 0.74 GP6 (0.65) AGTR2AGTR1
SCHEMBL7612129 0.74 AGTR1 (0.57) AGTR2AGTR1
SCHEMBL10476021 0.73 AGTR2 (0.65) AGTR2AGTR1
SCHEMBL8550440 0.73 AGTR2 (0.64) AGTR2AGTR1
SCHEMBL8553199 0.73 AGTR2 (0.62) AGTR2
SCHEMBL8550489 0.72 AGTR2 (0.65) AGTR2AGTR1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-5977155-A CARDIOVASCULAR, KIDNEYS HOECHST MARION ROUSSEL (FR) 1999-11-02 US disclosed