Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK8 | P45983 | 4/20 | 0.55 |
| ▸ | MAPK10 | P53779 | 4/20 | 0.55 |
| ▸ | MAPT | P10636 | 1/20 | 0.52 |
| ▸ | USP2 | O75604 | 1/20 | 0.51 |
| ▸ | HTT | P42858 | 2/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.51 |
| ▸ | LMNA | P02545 | 1/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.48 |
| ▸ | HPGD | P15428 | 1/20 | 0.47 |
| ▸ | TSHR | P16473 | 1/20 | 0.47 |
| ▸ | RECQL | P46063 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8350880 | 0.92 | MAPK8 (0.54) | MAPK8MAPK10MAPTHTTKMT2A | |
| SCHEMBL8349440 | 0.85 | BTK (0.54) | MAPTUSP2HTTKMT2A | |
| SCHEMBL14348419 | 0.83 | ALDH1A1 (0.53) | MAPK8MAPK10MAPTHTTLMNA | |
| SCHEMBL8351171 | 0.80 | MAPK10 (0.58) | MAPK8MAPK10MAPTKMT2AALDH1A1 | |
| SCHEMBL8349127 | 0.77 | BTK (0.56) | MAPK8 | |
| SCHEMBL8351466 | 0.77 | ROCK2 (0.64) | MAPK8MAPK10LMNA | |
| SCHEMBL13161966 | 0.75 | USP2 (0.72) | USP2HTTKMT2ALMNAALDH1A1 | |
| SCHEMBL29437185 | 0.74 | RECQL (0.58) | USP2HTTKMT2ALMNAALDH1A1 | |
| SCHEMBL21246564 | 0.74 | RECQL (0.58) | USP2HTTKMT2ALMNAALDH1A1 | |
| SCHEMBL8352104 | 0.74 | CFD (0.59) | MAPK8MAPK10HTTLMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7312227-B2 | Compositions useful as inhibitors of JAK and other protein kinases | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2007-12-25 | — | — | US | disclosed |
| US-7312227-B2 | Compositions useful as inhibitors of JAK and other protein kinases | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2007-12-25 | — | — | US | disclosed |
| WO-2004041789-A1 | COMPOSITIONS USEFUL AS INHIBITORS OF JAK AND OTHER PROTEIN KINASES | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2004-05-21 | — | — | WO | disclosed |