Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK8 | P45983 | 7/20 | 0.54 |
| ▸ | MAPK10 | P53779 | 7/20 | 0.54 |
| ▸ | MAPT | P10636 | 4/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.48 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.47 |
| ▸ | HTT | P42858 | 1/20 | 0.46 |
| ▸ | MEN1 | O00255 | 2/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.45 |
| ▸ | POLB | P06746 | 1/20 | 0.45 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.45 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.44 |
| ▸ | RPS6KA5 | O75582 | 1/20 | 0.44 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.44 |
| ▸ | PRKCG | P05129 | 1/20 | 0.44 |
| ▸ | PRKACA | P17612 | 1/20 | 0.44 |
| ▸ | RPS6KB1 | P23443 | 1/20 | 0.44 |
| ▸ | AKT1 | P31749 | 1/20 | 0.44 |
| ▸ | GSK3A | P49840 | 1/20 | 0.44 |
| ▸ | GSK3B | P49841 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8350684 | 0.92 | MAPK8 (0.55) | MAPK8MAPK10MAPTHTTKMT2A | |
| SCHEMBL14348419 | 0.89 | ALDH1A1 (0.53) | MAPK8MAPK10MAPTSMN1; SMN2HTT | |
| SCHEMBL8351171 | 0.85 | MAPK10 (0.58) | MAPK8MAPK10MAPTMEN1KMT2A | |
| SCHEMBL8351466 | 0.84 | ROCK2 (0.64) | MAPK8MAPK10MAPK1POLBROCK2 | |
| SCHEMBL8349127 | 0.82 | BTK (0.56) | MAPK8GSK3BPRKCDPIK3CAJAK2 | |
| SCHEMBL8352104 | 0.81 | CFD (0.59) | MAPK8MAPK10SMN1; SMN2HTTROCK2 | |
| SCHEMBL12391553 | 0.81 | HTT (0.59) | SMN1; SMN2MAPK1HTTMEN1KMT2A | |
| SCHEMBL8351537 | 0.78 | RXFP1 (0.54) | MAPK8MAPK10MAPTHTTKMT2A | |
| SCHEMBL1519014 | 0.77 | SMN1; SMN2 (0.60) | MAPK8MAPK10SMN1; SMN2MAPK1HTT | |
| SCHEMBL8349440 | 0.76 | BTK (0.54) | MAPTHTTKMT2APRKCGPRKCD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7312227-B2 | Compositions useful as inhibitors of JAK and other protein kinases | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2007-12-25 | — | — | US | disclosed |
| US-7312227-B2 | Compositions useful as inhibitors of JAK and other protein kinases | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2007-12-25 | — | — | US | disclosed |
| WO-2004041789-A1 | COMPOSITIONS USEFUL AS INHIBITORS OF JAK AND OTHER PROTEIN KINASES | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2004-05-21 | — | — | WO | disclosed |