Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 1/20 | 0.63 |
| ▸ | TK1 | P04183 | 4/20 | 0.60 |
| ▸ | TYMS | P04818 | 1/20 | 0.56 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL210837 | 0.91 | POLB (0.63) | POLBTK1 | |
| SCHEMBL7537922 | 0.89 | POLB (0.61) | POLBTK1TYMS | |
| SCHEMBL8425023 | 0.89 | POLB (0.61) | POLBTK1TYMS | |
| SCHEMBL19101649 | 0.89 | POLB (0.66) | POLBTK1TYMS | |
| SCHEMBL28399790 | 0.89 | POLB (0.66) | POLBTK1TYMS | |
| SCHEMBL17514032 | 0.89 | POLB (0.66) | POLBTK1TYMS | |
| SCHEMBL1764557 | 0.88 | TK1 (0.65) | POLBTK1TYMS | |
| SCHEMBL316664 | 0.88 | POLB (0.67) | POLBTK1TYMS | |
| SCHEMBL646741 | 0.88 | POLB (0.67) | POLBTK1TYMS | |
| SCHEMBL6379335 | 0.86 | POLB (0.68) | POLBTK1TYMS |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5929226-A | THREE OR MORE BUT NOT ALL NUCLEOTIDES ARE CONNECTED WITH METHYLPHOSPHONOTHIOATE LINKAGES WHERE SULFUR IS NOT BRIDGING ATOM; INCREASED RESISTANCE TO NUCLEASES, INCREASED DUPLEX STABILITY | HYBRIDON, INC. (US) | 1999-07-27 | — | — | US | disclosed |
| EP-0652890-B1 | OLIGONUCLEOTIDE ALKYLPHOSPHONOTHIOATES | HYBRIDON INC (US) | 1998-01-14 | — | — | EP | disclosed |
| EP-0652890-A1 | OLIGONUCLEOTIDE ALKYLPHOSPHONOTHIOATES | HYBRIDON, Inc. (US) | 1995-05-17 | — | — | EP | disclosed |
| WO-1994002499-A1 | OLIGONUCLEOTIDE ALKYLPHOSPHONOTHIOATES | HYBRIDON, INC. (US) | 1994-02-03 | — | — | WO | disclosed |