Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 5/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.46 |
| ▸ | BCHE | P06276 | 2/20 | 0.40 |
| ▸ | ACHE | P22303 | 2/20 | 0.40 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.39 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 2/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.35 |
| ▸ | APP | P05067 | 1/20 | 0.35 |
| ▸ | KAT2B | Q92831 | 4/20 | 0.35 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
| ▸ | PKM | P14618 | 1/20 | 0.35 |
| ▸ | PRMT5 | O14744 | 1/20 | 0.35 |
| ▸ | WDR77 | Q9BQA1 | 1/20 | 0.35 |
| ▸ | HCAR3 | P49019 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8349257 | 0.90 | MAPT (0.44) | MAPTALDH1A1BCHEACHENPSR1 | |
| SCHEMBL9498147 | 0.85 | ALDH1A1 (0.48) | MAPTALDH1A1BCHEACHENPSR1 | |
| SCHEMBL6150864 | 0.84 | MAPT (0.50) | MAPTALDH1A1BCHEACHELMNA | |
| SCHEMBL8355249 | 0.84 | MAPT (0.47) | MAPTALDH1A1BCHEACHENPSR1 | |
| SCHEMBL8355335 | 0.83 | MAPT (0.51) | MAPTALDH1A1BCHEACHELMNA | |
| SCHEMBL10620161 | 0.77 | HDAC1 (0.42) | MAPTALDH1A1NPSR1HDAC1LMNA | |
| SCHEMBL10610115 | 0.76 | MAPT (0.50) | MAPTALDH1A1BCHEACHENPSR1 | |
| SCHEMBL11490739 | 0.75 | TSHR (0.45) | MAPTALDH1A1NPSR1LMNASMN1; SMN2 | |
| SCHEMBL18392808 | 0.75 | MAPT (0.46) | MAPTALDH1A1NPSR1HDAC1LMNA | |
| SCHEMBL11316660 | 0.75 | ALDH1A1 (0.53) | MAPTALDH1A1NPSR1HDAC1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5874618-A | REACTING 2-NITRO-PARAPHENYLENEDIAMINES SUBSTITUTED AT 5-POSITION BY HALOGEN ATOM WITH MERCAPTAN DERIVATIVE OR SALT IN A SOLVENT, FURTHER OXIDIZING FOR SULFUR; USEFUL AS HAIR DYE; REDUCED ALLERGIES; WASHING STABILITY | L'OREAL (FR) | 1999-02-23 | — | — | US | claimed |
| EP-0673926-B1 | 2-Nitro-p-phenylenediamines having a sulfur atom in position 5, process for their preparation, dye compositions containing them and their use for dyeing keratinic fibres | OREAL (FR) | 1997-04-09 | — | — | EP | claimed |
| US-5874618-A | REACTING 2-NITRO-PARAPHENYLENEDIAMINES SUBSTITUTED AT 5-POSITION BY HALOGEN ATOM WITH MERCAPTAN DERIVATIVE OR SALT IN A SOLVENT, FURTHER OXIDIZING FOR SULFUR; USEFUL AS HAIR DYE; REDUCED ALLERGIES; WASHING STABILITY | L'OREAL (FR) | 1999-02-23 | — | — | US | disclosed |
| US-5735910-A | DIRECT HAIR DYES; WASHFASTNESS, COLORFASTNESS | L'OREAL (FR) | 1998-04-07 | — | — | US | disclosed |