Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK10 | P53779 | 12/20 | 0.58 |
| ▸ | MAPK8 | P45983 | 9/20 | 0.58 |
| ▸ | MAPK14 | Q16539 | 3/20 | 0.52 |
| ▸ | PIP5K1C | O60331 | 3/20 | 0.51 |
| ▸ | PIK3CA | P42336 | 3/20 | 0.51 |
| ▸ | HPGD | P15428 | 1/20 | 0.50 |
| ▸ | PIP5K1B | O14986 | 1/20 | 0.49 |
| ▸ | PIP5K1A | Q99755 | 1/20 | 0.49 |
| ▸ | JAK2 | O60674 | 1/20 | 0.49 |
| ▸ | TYK2 | P29597 | 1/20 | 0.49 |
| ▸ | MEN1 | O00255 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.47 |
| ▸ | GAA | P10253 | 1/20 | 0.47 |
| ▸ | MAPT | P10636 | 1/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.47 |
| ▸ | SMO | Q99835 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8350880 | 0.85 | MAPK8 (0.54) | MAPK10MAPK8MAPK14PIP5K1CPIK3CA | |
| SCHEMBL14348419 | 0.82 | ALDH1A1 (0.53) | MAPK10MAPK8HPGDALDH1A1MAPT | |
| SCHEMBL8351537 | 0.82 | RXFP1 (0.54) | MAPK10MAPK8MAPK14PIP5K1CPIK3CA | |
| SCHEMBL8351036 | 0.82 | MAPK8 (0.66) | MAPK10MAPK8MAPK14PIP5K1CPIK3CA | |
| SCHEMBL8351530 | 0.81 | MAPK10 (0.56) | MAPK10MAPK8MAPK14 | |
| SCHEMBL8350684 | 0.80 | MAPK8 (0.55) | MAPK10MAPK8HPGDALDH1A1MAPT | |
| SCHEMBL14348390 | 0.80 | JAK2 (0.64) | MAPK8PIK3CAJAK2 | |
| SCHEMBL1518944 | 0.78 | MAPK10 (0.64) | MAPK10MAPK8MAPK14PIP5K1CPIK3CA | |
| SCHEMBL1518723 | 0.78 | CNR1 (0.69) | MAPK10MAPK8MAPK14PIP5K1CPIK3CA | |
| SCHEMBL1518824 | 0.78 | PIP5K1C (0.68) | MAPK10MAPK8MAPK14PIP5K1CPIK3CA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7312227-B2 | Compositions useful as inhibitors of JAK and other protein kinases | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2007-12-25 | — | — | US | disclosed |
| US-7312227-B2 | Compositions useful as inhibitors of JAK and other protein kinases | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2007-12-25 | — | — | US | disclosed |
| WO-2004041789-A1 | COMPOSITIONS USEFUL AS INHIBITORS OF JAK AND OTHER PROTEIN KINASES | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2004-05-21 | — | — | WO | disclosed |