Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSP90AA1 | P07900 | 2/20 | 0.39 |
| ▸ | CCNT1 | O60563 | 2/20 | 0.33 |
| ▸ | CDK9 | P50750 | 2/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | TSHR | P16473 | 1/20 | 0.32 |
| ▸ | TLR8 | Q9NR97 | 1/20 | 0.32 |
| ▸ | TLR7 | Q9NYK1 | 1/20 | 0.32 |
| ▸ | DHFR | P00374 | 2/20 | 0.32 |
| ▸ | NUDT1 | P36639 | 1/20 | 0.32 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.31 |
| ▸ | LMNA | P02545 | 1/20 | 0.31 |
| ▸ | MAPT | P10636 | 1/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.31 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23534954 | 0.73 | NUDT1 (0.41) | HSP90AA1DHFRNUDT1MEN1LMNA | |
| SCHEMBL29948217 | 0.73 | NUDT1 (0.41) | HSP90AA1DHFRNUDT1MEN1LMNA | |
| SCHEMBL26083267 | 0.71 | TSHR (0.32) | CCNT1CDK9TSHRTLR8TLR7 | |
| SCHEMBL26083269 | 0.70 | ALDH1A1 (0.36) | CCNT1CDK9KDM4ETSHRMEN1 | |
| SCHEMBL31403483 | 0.70 | TLR8 (0.38) | CCNT1CDK9TSHRTLR8TLR7 | |
| SCHEMBL22834670 | 0.69 | LMNA (0.40) | HSP90AA1KDM4ENUDT1HSP90AB1MEN1 | |
| SCHEMBL29652037 | 0.69 | LMNA (0.40) | HSP90AA1KDM4ENUDT1HSP90AB1MEN1 | |
| SCHEMBL6664133 | 0.69 | HTT (0.41) | CCNT1CDK9KDM4ETSHRMEN1 | |
| SCHEMBL15260198 | 0.68 | TSHR (0.39) | KDM4ETSHRLMNAMAPTKMT2A | |
| SCHEMBL22234608 | 0.67 | NUDT1 (0.42) | DHFRNUDT1MEN1LMNAMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5958904-A | Phosphonomethyl-imidazo 1,2-A! pyrimidine-2-carboxylic acid compounds for treatment of neurotoxic injury | G.D. SEARLE & CO. (US) | 1999-09-28 | — | — | US | disclosed |
| US-5482933-A | ANOXIA, ISCHEMIA | G. D. SEARLE & CO. (US) | 1996-01-09 | — | — | US | disclosed |
| US-5480876-A | FROM ANOXIA OR ISCHEMIA | G. D. SEARLE & CO. (US) | 1996-01-02 | — | — | US | disclosed |
| US-5302586-A | Antiischemic and -hypoxia agents, particularly after a stroke, cardiac arrest, hypoglycemia or perinatal asphxia | G. D. SEARLE & CO. (US) | 1994-04-12 | — | — | US | disclosed |
| US-5252563-A | 5,6,7,8-tetrahydro-imidazo[1,2-a]pyrimidine compounds for treatment of neurotoxic injury | G. D. SEARLE & COMPANY (US) | 1993-10-12 | — | — | US | disclosed |