Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PSIP1 | O75475 | 1/20 | 0.44 |
| ▸ | HSD11B1 | P28845 | 3/20 | 0.43 |
| ▸ | BCAT1 | P54687 | 1/20 | 0.40 |
| ▸ | MMP1 | P03956 | 3/20 | 0.39 |
| ▸ | MMP7 | P09237 | 3/20 | 0.39 |
| ▸ | MMP12 | P39900 | 3/20 | 0.39 |
| ▸ | MMP13 | P45452 | 3/20 | 0.39 |
| ▸ | ACE | P12821 | 2/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
| ▸ | MMP2 | P08253 | 1/20 | 0.38 |
| ▸ | MMP9 | P14780 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
| ▸ | CCR5 | P51681 | 1/20 | 0.37 |
| ▸ | GAA | P10253 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL835334 | 1.00 | PSIP1 (0.44) | PSIP1HSD11B1BCAT1MMP1MMP7 | |
| SCHEMBL1476603 | 1.00 | PSIP1 (0.44) | PSIP1HSD11B1BCAT1MMP1MMP7 | |
| SCHEMBL1700880 | 0.81 | MMP2 (0.50) | PSIP1HSD11B1MMP1MMP7MMP12 | |
| Hydrochloric Acid SCHEMBL5120935 | 0.80 | MMP2 (0.49) | PSIP1HSD11B1MMP1MMP7MMP12 | |
| SCHEMBL12486241 | 0.76 | PSIP1 (0.48) | PSIP1HSD11B1MMP1MMP7MMP12 | |
| SCHEMBL10800445 | 0.73 | CA1 (0.44) | MMP1MMP13L3MBTL1MMP2MMP9 | |
| SCHEMBL1476455 | 0.72 | HSD11B1 (0.38) | PSIP1HSD11B1MMP1MMP7MMP12 | |
| SCHEMBL833215 | 0.72 | HSD11B1 (0.38) | PSIP1HSD11B1MMP1MMP7MMP12 | |
| SCHEMBL6559430 | 0.71 | ATM (0.46) | PSIP1HSD11B1MMP1MMP7MMP12 | |
| SCHEMBL6683343 | 0.71 | MMP2 (0.68) | PSIP1HSD11B1MMP1MMP7MMP12 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8143410-B2 | Kinase inhibitors | ALLERGAN, INC. (US) | 2012-03-27 | — | — | US | disclosed |
| US-20110263611-A1 | Kinase Inhibitors | ALLERGAN, INC. | 2011-10-27 | — | — | US | disclosed |
| US-7915443-B2 | Sulfoximines as kinase inhibitors | ALLERGAN, INC. (US) | 2011-03-29 | — | — | US | disclosed |
| US-20090099181-A1 | SULFOXIMINES AS KINASE INHIBITORS | ALLERGAN, INC. | 2009-04-16 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110263611-A1 | Kinase Inhibitors | PTK2, MAP3K6, MAP3K20 | PSIP1 3229/4885HSD11B1 4291/4885BCAT1 2472/4885 |
| US-20090099181-A1 | SULFOXIMINES AS KINASE INHIBITORS | SRC, PTK2B, TYRO3 | PSIP1 2880/4885HSD11B1 3429/4885BCAT1 1537/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.