Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC3 | O15379 | 3/20 | 0.54 |
| ▸ | HDAC1 | Q13547 | 3/20 | 0.54 |
| ▸ | HDAC2 | Q92769 | 3/20 | 0.54 |
| ▸ | NCOR2 | Q9Y618 | 3/20 | 0.54 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.49 |
| ▸ | MEN1 | O00255 | 2/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.46 |
| ▸ | NUDT1 | P36639 | 1/20 | 0.46 |
| ▸ | GAA | P10253 | 2/20 | 0.45 |
| ▸ | LMNA | P02545 | 2/20 | 0.45 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.45 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.45 |
| ▸ | MAPT | P10636 | 1/20 | 0.45 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.45 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.45 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.44 |
| ▸ | LDHA | P00338 | 1/20 | 0.44 |
| ▸ | LDHB | P07195 | 1/20 | 0.44 |
| ▸ | CRHBP | P24387 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15722551 | 1.00 | HDAC3 (0.54) | HDAC3HDAC1HDAC2NCOR2ALDH1A1 | |
| SCHEMBL15722447 | 1.00 | HDAC3 (0.54) | HDAC3HDAC1HDAC2NCOR2ALDH1A1 | |
| SCHEMBL21427415 | 0.87 | GAA (0.53) | HDAC3HDAC1HDAC2NCOR2ALDH1A1 | |
| SCHEMBL18027646 | 0.85 | MEN1 (0.53) | ALDH1A1KDM4EMEN1KMT2ANUDT1 | |
| SCHEMBL28478972 | 0.84 | MAPKAPK2 (0.46) | HDAC3HDAC1HDAC2NCOR2ALDH1A1 | |
| SCHEMBL9193640 | 0.84 | HDAC1 (0.65) | HDAC3HDAC1HDAC2NCOR2ALDH1A1 | |
| SCHEMBL30894541 | 0.81 | KDM4E (0.62) | HDAC3HDAC1HDAC2NCOR2KDM4E | |
| SCHEMBL15176894 | 0.79 | CRHBP (0.43) | ALDH1A1KDM4EMEN1KMT2ANUDT1 | |
| SCHEMBL14247790 | 0.79 | L3MBTL1 (0.44) | HDAC3HDAC1HDAC2NCOR2ALDH1A1 | |
| SCHEMBL14247727 | 0.79 | L3MBTL1 (0.44) | HDAC3HDAC1HDAC2NCOR2ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2925761-B1 | TRIAZOLOPYRAZINES AS BRD4 INHIBITORS FOR USE IN THE TREATMENT OF CANCER | BOEHRINGER INGELHEIM INT (DE) | 2017-07-05 | — | — | EP | disclosed |
| WO-2003002524-A2 | UREA DERIVATIVES WITH ANTIPROTEOLYTIC ACTIVITY | AVENTIS PHARMA DEUTSCHLAND GMBH (DE) | 2003-01-09 | — | — | WO | disclosed |