Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC1 | Q13547 | 8/20 | 0.65 |
| ▸ | HDAC3 | O15379 | 6/20 | 0.65 |
| ▸ | HDAC2 | Q92769 | 6/20 | 0.65 |
| ▸ | NCOR2 | Q9Y618 | 4/20 | 0.65 |
| ▸ | LDHA | P00338 | 3/20 | 0.51 |
| ▸ | LDHB | P07195 | 3/20 | 0.51 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.47 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.46 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.45 |
| ▸ | NR1H4 | Q96RI1 | 1/20 | 0.44 |
| ▸ | MAPK13 | O15264 | 1/20 | 0.44 |
| ▸ | MAPK12 | P53778 | 1/20 | 0.44 |
| ▸ | MAPK11 | Q15759 | 1/20 | 0.44 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.44 |
| ▸ | ASPH | Q12797 | 1/20 | 0.44 |
| ▸ | RIOX2 | Q8IUF8 | 1/20 | 0.44 |
| ▸ | KDM8 | Q8N371 | 1/20 | 0.44 |
| ▸ | EGFR | P00533 | 1/20 | 0.44 |
| ▸ | PTGER4 | P35408 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9688475 | 0.85 | HDAC1 (0.59) | HDAC1HDAC3HDAC2NCOR2KDM4E | |
| SCHEMBL15722447 | 0.84 | HDAC3 (0.54) | HDAC1HDAC3HDAC2NCOR2LDHA | |
| SCHEMBL15722551 | 0.84 | HDAC3 (0.54) | HDAC1HDAC3HDAC2NCOR2LDHA | |
| SCHEMBL8353923 | 0.84 | HDAC3 (0.54) | HDAC1HDAC3HDAC2NCOR2LDHA | |
| SCHEMBL21427415 | 0.79 | GAA (0.53) | HDAC1HDAC3HDAC2NCOR2LDHA | |
| SCHEMBL11259360 | 0.76 | KDM4E (0.58) | HDAC1HDAC3HDAC2NCOR2LDHA | |
| SCHEMBL21925191 | 0.74 | LNPEP (0.53) | HDAC1HDAC3HDAC2NCOR2LDHA | |
| SCHEMBL9706349 | 0.74 | HDAC1 (0.49) | HDAC1HDAC3HDAC2NCOR2KDM4E | |
| SCHEMBL1983877 | 0.74 | HDAC1 (0.49) | HDAC1HDAC3HDAC2NCOR2KDM4E | |
| SCHEMBL24890548 | 0.74 | HDAC1 (0.74) | HDAC1HDAC3HDAC2NCOR2MAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0399732-B1 | Benzimidazole derivatives | ZENECA LTD (GB) | 1995-07-26 | — | — | EP | disclosed |
| EP-0399732-A1 | Benzimidazole derivatives | ZENECA LIMITED (GB) | 1990-11-28 | — | — | EP | disclosed |