Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AKR1C3 | P42330 | 6/20 | 0.62 |
| ▸ | AKR1C2 | P52895 | 5/20 | 0.62 |
| ▸ | PTGS2 | P35354 | 8/20 | 0.55 |
| ▸ | PTGS1 | P23219 | 6/20 | 0.55 |
| ▸ | AR | P10275 | 2/20 | 0.55 |
| ▸ | AKR1C4 | P17516 | 2/20 | 0.55 |
| ▸ | AKR1C1 | Q04828 | 2/20 | 0.55 |
| ▸ | ABCB1 | P08183 | 2/20 | 0.55 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.55 |
| ▸ | MEN1 | O00255 | 1/20 | 0.55 |
| ▸ | PTGES | O14684 | 1/20 | 0.55 |
| ▸ | ABCC3 | O15438 | 1/20 | 0.55 |
| ▸ | ABCC4 | O15439 | 1/20 | 0.55 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.55 |
| ▸ | MT-CO2 | P00403 | 1/20 | 0.55 |
| ▸ | LMNA | P02545 | 1/20 | 0.55 |
| ▸ | ALB | P02768 | 1/20 | 0.55 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.55 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.55 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.55 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8354825 | 0.92 | AKR1C3 (0.51) | AKR1C3AKR1C2PTGS2PTGS1AR | |
| SCHEMBL8354130 | 0.87 | LMNA (0.54) | AKR1C3AKR1C2PTGS2PTGS1AR | |
| SCHEMBL4377895 | 0.84 | AKR1C3 (0.57) | AKR1C3AKR1C2PTGS2 | |
| SCHEMBL5554558 | 0.84 | AKR1C3 (0.47) | AKR1C3AKR1C2PTGS2PTGS1PPARG | |
| SCHEMBL8360216 | 0.82 | CNR2 (0.46) | AKR1C3AKR1C2PTGS2AKR1C4AKR1C1 | |
| SCHEMBL10771271 | 0.78 | AKR1C3 (0.56) | AKR1C3AKR1C2PTGS2PTGS1AR | |
| SCHEMBL11037919 | 0.77 | AKR1C3 (1.00) | AKR1C3AKR1C2PTGS2PTGS1AR | |
| SCHEMBL29481380 | 0.77 | AKR1C3 (1.00) | AKR1C3AKR1C2PTGS2PTGS1AR | |
| SCHEMBL1101913 | 0.76 | PTGS2 (0.71) | AKR1C3AKR1C2PTGS2PTGS1AR | |
| SCHEMBL15684644 | 0.74 | AKR1C3 (0.77) | AKR1C3AKR1C2PTGS2PTGS1AR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 36 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2057139-B1 | HYDROGEN SULFIDE DERIVATIVES OF NON-STEROIDAL ANTI-INFLAMMATORY DRUGS | ANTIBE THERAPEUTICS INC (US) | 2013-09-04 | — | — | EP | claimed |
| US-20080132562-A1 | TETRONIC AND TETRAMIC ACIDS | GODEL THIERRY | 2008-06-05 | — | — | US | claimed |
| EP-1689729-A1 | TETRONIC AND TETRAMIC ACIDS AS INHIBITORS OF BETA-SECREASE | F. Hoffmann-La Roche AG (CH) | 2006-08-16 | — | — | EP | claimed |
| WO-2005058857-A1 | TETRONIC AND TETRAMIC ACIDS AS INHIBITORS OF BETA-SECREASE | F. HOFFMANN-LA ROCHE AG (CH) | 2005-06-30 | — | — | WO | claimed |
| US-20050119329-A1 | Tetronic and tetramic acids | HOFFMANN-LA ROCHE INC. | 2005-06-02 | — | — | US | claimed |
| EP-0237495-B1 | HALOGENIDES OF THE ESTER OF 2,N,N,N-DIMETHYL-ALKYL-AMINO-ETHANOL WITH SUBSTITUTED ACETIC ACID AND PHARMACEUTICAL COMPOSITIONS HAVING ANTIINFLAMMATORY AND ANTISEPTIC ACTIVITIES CONTAINING SAME | Sigma-Tau Industrie Farmaceutiche Riunite S.p.A. (IT) | 1990-09-26 | — | — | EP | claimed |
| EP-0195582-B1 | 5-AMINOSALICYLIC ACID DERIVATIVES OF NON-STEROIDAL ANTIINFLAMMATORY ACIDS | SMITH KLINE DAUELSBERG GmbH (DE) | 1990-01-24 | — | — | EP | claimed |
| EP-0237495-A2 | Halogenides of the ester of 2,N,N,N-dimethyl-alkyl-amino-ethanol with substituted acetic acid and pharmaceutical compositions having antiinflammatory and antiseptic activities containing same | Sigma-Tau Industrie Farmaceutiche Riunite S.p.A. (IT) | 1987-09-16 | — | — | EP | claimed |
| WO-1986005485-A1 | AMIDES OF NON-STEROIDAL ANTI-INFLAMMATORY CARBOXYLIC ACIDS | SMITH KLINE DAUELSBERG GMBH (DE) | 1986-09-25 | — | — | WO | claimed |
| JP-62096480-A | — | — | None | — | — | JP | disclosed |
| JP-60051188-A | — | — | None | — | — | JP | disclosed |
| WO-2012142208-A1 | BIFUNCTIONAL AKR1C3 INHIBITORS/ANDROGEN RECEPTOR MODULATORS AND METHODS OF USE THEREOF | THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA (US) | 2012-10-18 | — | — | WO | disclosed |
| US-20080132562-A1 | TETRONIC AND TETRAMIC ACIDS | GODEL THIERRY | 2008-06-05 | — | — | US | disclosed |
| EP-1689729-A1 | TETRONIC AND TETRAMIC ACIDS AS INHIBITORS OF BETA-SECREASE | F. Hoffmann-La Roche AG (CH) | 2006-08-16 | — | — | EP | disclosed |
| EP-0195582-A1 | 5-Aminosalicylic acid derivatives of non-steroidal antiinflammatory acids | SMITH KLINE DAUELSBERG GmbH (DE) | 1986-09-24 | — | — | EP | disclosed |
| EP-0163286-A2 | Acylated sugars, method for their preparation and their use | CIBA-GEIGY AG (CH) | 1985-12-04 | — | — | EP | disclosed |
| JP-S6051188-A | NOVEL 1,2,4-OXADIAZOLE DERIVATIVE | SUMITOMO CHEM CO LTD | 1985-03-22 | — | — | JP | disclosed |
| US-4362738-A | ANTIINFLAMMATORIES | DR. KARL THOMAE GMBH (DE) | 1982-12-07 | — | — | US | disclosed |
| EP-0024282-A1 | Benzoyl derivatives, their preparation and their use as medicines | Dr. Karl Thomae GmbH (DE) | 1981-03-04 | — | — | EP | disclosed |
| JP-S0651188-A | — | — | 0001-01-01 | — | — | JP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080132562-A1 | TETRONIC AND TETRAMIC ACIDS | BACE1, PSEN1, BACE2 | AKR1C3 1354/4885AKR1C2 2018/4885PTGS2 4159/4885 |
| US-20050119329-A1 | Tetronic and tetramic acids | BACE1, PSEN1, BACE2 | AKR1C3 1354/4885AKR1C2 2018/4885PTGS2 4159/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.