Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AKR1C3 | P42330 | 11/20 | 0.47 |
| ▸ | AKR1C2 | P52895 | 9/20 | 0.47 |
| ▸ | NPC1 | O15118 | 1/20 | 0.45 |
| ▸ | RAB9A | P51151 | 1/20 | 0.45 |
| ▸ | PPARG | P37231 | 5/20 | 0.44 |
| ▸ | PPARA | Q07869 | 3/20 | 0.44 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.42 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8354825 | 0.89 | AKR1C3 (0.51) | AKR1C3AKR1C2RAB9APPARGPTGS2 | |
| SCHEMBL4377895 | 0.88 | AKR1C3 (0.57) | AKR1C3AKR1C2PTGS2 | |
| SCHEMBL5797505 | 0.88 | TRPV1 (0.40) | AKR1C3AKR1C2PPARGPPARA | |
| SCHEMBL4663300 | 0.84 | AKR1C3 (0.62) | AKR1C3AKR1C2RAB9APPARGPTGS2 | |
| SCHEMBL8354130 | 0.84 | LMNA (0.54) | AKR1C3AKR1C2RAB9APPARGPTGS2 | |
| SCHEMBL5554732 | 0.84 | PTGS2 (0.45) | AKR1C3AKR1C2PPARGPPARAPTGS2 | |
| SCHEMBL5560384 | 0.81 | AKR1C2 (0.39) | AKR1C3AKR1C2PPARG | |
| SCHEMBL8360216 | 0.79 | CNR2 (0.46) | AKR1C3AKR1C2PTGS2 | |
| SCHEMBL5554099 | 0.73 | AKR1C3 (0.83) | AKR1C3AKR1C2RAB9APPARGPTGS2 | |
| SCHEMBL5554095 | 0.73 | AKR1C3 (0.56) | AKR1C3AKR1C2RAB9APPARGPPARA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1643961-A4 | COX-2 AND FAAH INHIBITORS | MICROBIA INC (US) | 2007-09-12 | — | — | EP | disclosed |
| WO-2006050120-A2 | SYNTHESIS OF COX-2 AND FAAH INHIBITORS | MICROBIA, INC. (US) | 2006-05-11 | — | — | WO | disclosed |
| EP-1643961-A2 | COX-2 AND FAAH INHIBITORS | Microbia, Inc. (US) | 2006-04-12 | — | — | EP | disclosed |
| WO-2005002525-A2 | COX-2 AND FAAH INHIBITORS | MICROBIA, INC. (US) | 2005-01-13 | — | — | WO | disclosed |