Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.42 |
| ▸ | TSHR | P16473 | 2/20 | 0.42 |
| ▸ | LMNA | P02545 | 2/20 | 0.41 |
| ▸ | ABL1 | P00519 | 1/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.37 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
| ▸ | CFTR | P13569 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | PTGS2 | P35354 | 3/20 | 0.36 |
| ▸ | GAA | P10253 | 2/20 | 0.36 |
| ▸ | CA2 | P00918 | 2/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.35 |
| ▸ | EPAS1 | Q99814 | 1/20 | 0.34 |
| ▸ | CA1 | P00915 | 1/20 | 0.34 |
| ▸ | CA5A | P35218 | 1/20 | 0.34 |
| ▸ | CA9 | Q16790 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8356473 | 0.83 | MAPT (0.38) | ALDH1A1TSHRLMNAKDM4EHSD17B10 | |
| SCHEMBL3215571 | 0.83 | KDM4E (0.38) | ALDH1A1TSHRLMNAKDM4EHSD17B10 | |
| SCHEMBL8354895 | 0.81 | CA2 (0.41) | ALDH1A1TSHRKDM4EHSD17B10SMN1; SMN2 | |
| SCHEMBL8355025 | 0.81 | ALDH1A1 (0.42) | ALDH1A1TSHRLMNAABL1KDM4E | |
| SCHEMBL15390859 | 0.78 | ABL1 (0.46) | ALDH1A1LMNAABL1KDM4ESMN1; SMN2 | |
| SCHEMBL1809801 | 0.78 | LMNA (0.46) | ALDH1A1TSHRLMNAKDM4EHSD17B10 | |
| SCHEMBL1017860 | 0.78 | KDM4E (0.45) | ALDH1A1TSHRLMNAKDM4EHSD17B10 | |
| SCHEMBL2511792 | 0.75 | GAA (0.45) | ALDH1A1TSHRLMNAABL1KDM4E | |
| SCHEMBL27630669 | 0.75 | ALDH1A1 (0.47) | ALDH1A1TSHRLMNAABL1KDM4E | |
| SCHEMBL8358401 | 0.75 | ALDH1A1 (0.42) | ALDH1A1TSHRLMNAKDM4EHSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6001881-A | Ortho-substituted benzoylguanidines, a process for their preparation, their use as a medicament or diagnostic agent, and a medicament comprising them | HOECHST AKTIENGESELLSCHAFT (DE) | 1999-12-14 | — | — | US | disclosed |