Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR1B | P28222 | 2/20 | 0.39 |
| ▸ | HTR1D | P28221 | 1/20 | 0.39 |
| ▸ | THRB | P10828 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.37 |
| ▸ | DRD2 | P14416 | 1/20 | 0.36 |
| ▸ | DRD1 | P21728 | 1/20 | 0.36 |
| ▸ | DRD3 | P35462 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 4/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.35 |
| ▸ | RAD52 | P43351 | 3/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | PKM | P14618 | 1/20 | 0.35 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 2/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
| ▸ | NPC1 | O15118 | 1/20 | 0.33 |
| ▸ | TP53 | P04637 | 1/20 | 0.33 |
| ▸ | AGER | Q15109 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8358024 | 0.83 | HTR1B (0.47) | HTR1BHTR1DTHRBALDH1A1DRD2 | |
| SCHEMBL8357744 | 0.83 | THRB (0.40) | HTR1BHTR1DTHRBALDH1A1DRD2 | |
| SCHEMBL8356718 | 0.82 | THRB (0.39) | HTR1BHTR1DTHRBALDH1A1DRD2 | |
| SCHEMBL8361614 | 0.81 | HTR1B (0.46) | HTR1BHTR1DTHRBALDH1A1MEN1 | |
| SCHEMBL8356222 | 0.80 | THRB (0.38) | HTR1BHTR1DTHRBALDH1A1DRD2 | |
| SCHEMBL8552033 | 0.80 | LMNA (0.52) | MEN1KMT2AKDM4EMAPK1MAPT | |
| SCHEMBL8358531 | 0.74 | ALDH1A1 (0.48) | HTR1BHTR1DTHRBALDH1A1DRD2 | |
| SCHEMBL8357765 | 0.72 | SCD (0.37) | ALDH1A1NPC1 | |
| SCHEMBL8359946 | 0.70 | THRB (0.42) | THRBALDH1A1DRD2DRD1DRD3 | |
| SCHEMBL8355833 | 0.69 | THRB (0.40) | THRBALDH1A1MEN1KMT2ARAD52 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5919807-A | ANTICHOLESTEROL AGENTS | DR. KARL THOMAE GMBH (DE) | 1999-07-06 | — | — | US | disclosed |